PMID: 17909048

Zhang Y, Bressler JP, Neal J, Lal B, Bhang HE, Laterra J, Pomper MG
ABCG2/BCRP expression modulates D-Luciferin based bioluminescence imaging.
Cancer Res. 2007 Oct 1;67(19):9389-97., 2007-10-01 [PubMed]
Sentences
No. Mutations Sentence Comment
167 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 17909048:167:93
status: VERIFIED
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17909048:167:108
status: VERIFIED
view ABCG2 p.Arg482Gly details
 Cells engineered to express wild-type (wt) ABCG2/BCRP or mutant ABCG2/BCRP transporters T10 (R482T) and G2 (R482G) were transiently transfected with the CMV trifusion reporter and then seeded into 24-well plates for imaging in the presence or absence of transporter inhibitors (10). Login to comment 235 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 17909048:235:90
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17909048:235:100
status: VERIFIED
view ABCG2 p.Arg482Gly details
 Whereas D-luciferin proved to be a substrate of wt ABCG2/BCRP, single amino acid changes (R482T and R482G) within the transporter change the BLI output enhancement in response to various inhibitors. Login to comment