ABCMdb

PMID: 22509477

Mo W, Zhang JT
Human ABCG2: structure, function, and its role in multidrug resistance.
Int J Biochem Mol Biol. 2012;3(1):1-27. Epub 2011 Mar 30., [PubMed]

Sentences

No. Mutations Sentence Comment

204 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly ABCG2 p.Arg482Gly This inconsistency led to discovery of a gain of function ABCG2 mutant with R482G/T mutation [109, 110] Both the R482G and R482T mutants and the wild-type ABCG2 are able to efflux mitoxantrone, topotecan, SN-38, Hoechst 33342 [111] and BODIPY-prazosin [112]. Login to comment 205 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly However, the R482G and R482T mutants have higher affinity with anthracyclines, including doxorubicin, daunorubicin, epirubicin, as well as bisantrene, fluorescence dye rhodamine 123 and lysotracker green [112]. Login to comment 208 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Nevertheless, a study using IAARh123, the photoreactive analogue of rhodamine 123, has surprisingly shown that the wild type ABCG2 along with the two R482G and R482T mutants can all bind directly to IAARh123 although the wild type ABCG2 could not transport rhodamine [116]. Login to comment 247 ABCG2 p.Arg482Thr Some HIV protease inhibitors including ritonavir, saquinavir, nelfinavir, and iopinavir could effectively inhibit the transport activity of wild type ABCG2 but with less effect on R482T/G mutants [151, 152]. Login to comment 569 ABCG2 p.Arg482Thr [116] Alqawi O, Bates S and Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Login to comment 570 ABCG2 p.Arg482Thr [116] Alqawi O, Bates S and Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Login to comment 889 ABCG2 p.Gln141Lys ABCG2 p.Val12Met ABCG2 p.Gln126* The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine. Login to comment 895 ABCG2 p.Gln141Lys ABCG2 p.Val12Met ABCG2 p.Gln126* The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine. Login to comment