Mutations at homologous positions to ABCC7 p.Leu333
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Leu333Ala
p.Leu333Cys
|
N
N
D
N
N
D
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Ile328Cys
p.Lys329Ala
p.Lys329Cys
p.Lys329Glu
p.Gly330*
p.Gly330Cys
p.Ile331Cys
p.Ile332Cys
p.Ile332Lys
p.Arg334Trp
p.Arg334Leu
p.Arg334Gln
p.Arg334Cys
p.Arg334Ala
p.Arg334His
p.Arg334Glu
p.Arg334Lys
p.Arg334Asp
p.Arg334*
p.Arg334Thr
p.Lys335Glu
p.Lys335Ile
p.Lys335Phe
p.Lys335Ala
p.Lys335Cys
p.Lys335Gln
p.Lys335Asp
p.Lys335Arg
p.Lys335His
p.Ile336Lys
p.Ile336Ala
p.Ile336Cys
p.Ile336Leu
p.Phe337Ser
p.Phe337Ala
p.Phe337Tyr
p.Phe337Cys
p.Phe337Glu
p.Phe337Leu
p.Phe337Trp
p.Phe337Arg
p.Thr338Ile
p.Thr338Ala
p.Thr338Ser
p.Thr338Met
p.Thr338Glu
p.Thr338Gln
p.Thr338Cys
p.Thr338His
p.Thr338Phe
p.Thr338Asn
p.Thr338Val
p.Thr338Lys
p.Thr338Arg
|
N
N
?
N
N
?
D
N
?
D
N
?
-
-
D
D
D
D
D
D
?
N
N
?
N
N
?
D
D
D
D
N
D
N
D
D
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
-
-
D
D
N
D
D
N
?
D
N
?
D
D
?
D
N
?
D
D
?
N
N
?
D
N
?
N
N
?
D
N
?
D
D
D
D
N
?
D
N
?
D
N
?
D
D
?
D
D
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
D
D
N
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
N
?
D
N
?
D
D
?
D
D
?
|
| ABCC1 |
p.Asp578Arg
p.Gln580Ala
p.Thr581Ala
|
D
D
?
D
D
?
D
N
?
|
| ABCC2 |
p.Lys578Ala
|
D
D
?
|
| ABCC6 |
p.Met562Thr
p.Phe568Ser
|
D
D
D
D
D
D
|
| ABCC8 |
p.Glu568Lys
p.Ser574Gly
|
D
N
?
N
N
?
|
The alignment around the queried position:
ABCC7 297
A
N
S
S
-
-
-
D
G
A
I
I
D
373
ABCC1 540
K
S
A
Y
L
S
A
V
G
F
V
F
L
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
I
I
V
Q
A
S
V
S
L
K
R
L
R
I
618
ABCC2 537
L
A
F
S
Q
L
Q
C
V
V
I
F
V
F
Q
L
T
P
V
L
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
I
S
S
M
L
Q
A
V
S
T
E
R
L
E
K
615
ABCC3 526
R
A
Y
L
H
T
T
T
T
F
T
W
M
C
S
P
F
L
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
I
S
N
L
T
Q
A
S
V
S
L
K
R
I
Q
Q
604
ABCC4 311
L
R
S
S
C
L
R
G
M
N
L
A
S
F
F
S
A
S
K
I
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
I
V
S
A
I
V
S
I
R
R
I
Q
T
388
ABCC5 393
E
K
A
G
Y
F
Q
S
I
T
V
G
V
A
P
I
V
V
V
I
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
V
K
S
L
S
E
A
S
V
A
V
D
R
F
K
S
469
ABCC6 526
R
T
S
G
L
L
F
S
V
L
V
S
F
Q
V
S
T
F
L
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
I
H
S
L
V
Q
A
R
V
S
F
D
L
V
T
603
ABCC8 534
R
A
A
I
Y
T
S
I
S
I
F
M
N
T
A
I
I
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
V
S
T
K
A
L
V
S
Q
K
L
S
E
612
ABCC9 530
K
T
F
A
L
Y
T
S
L
S
I
F
M
N
A
A
I
P
I
A
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
V
R
A
V
K
A
I
I
S
V
Q
K
L
N
E
607
ABCC10 497
R
V
I
K
Y
L
D
A
A
C
V
Y
L
W
A
A
L
P
V
V
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
I
N
G
L
L
E
A
K
V
S
L
D
R
I
Q
L
573
ABCC11 377
E
K
C
G
L
V
Q
S
L
T
S
I
T
L
F
I
I
P
T
V
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
V
K
G
L
T
N
S
K
S
A
V
M
R
F
K
K
453
ABCC12 337
E
K
A
G
F
V
Q
S
G
N
S
A
L
A
P
I
V
S
T
I
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
I
K
A
M
A
E
A
N
V
S
L
R
R
M
K
K
413