ABCC9 p.Phe594Tyr
| Predicted by SNAP2: | A: N (61%), C: N (61%), D: D (59%), E: D (59%), G: N (57%), H: N (53%), I: N (57%), K: D (59%), L: N (53%), M: N (61%), N: N (61%), P: D (63%), Q: N (57%), R: N (53%), S: N (78%), T: N (82%), V: N (57%), W: D (71%), Y: N (53%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, G: D, H: D, I: N, K: D, L: N, M: N, N: D, P: D, Q: D, R: D, S: N, T: D, V: D, W: D, Y: N, |
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[hide] Transport of glutathione and glutathione conjugate... Trends Pharmacol Sci. 2006 Aug;27(8):438-46. Epub 2006 Jul 3. Cole SP, Deeley RG
Transport of glutathione and glutathione conjugates by MRP1.
Trends Pharmacol Sci. 2006 Aug;27(8):438-46. Epub 2006 Jul 3., [PMID:16820223]
Abstract [show]
Glutathione (GSH)-conjugated xenobiotics and GSH-conjugated metabolites (e.g. the cysteinyl leukotriene C4) must be exported from the cells in which they are formed before they can be eliminated from the body or act on their cellular targets. This efflux is often mediated by the multidrug resistance protein 1 (MRP1) transporter, which also confers drug resistance to tumour cells and can protect normal cells from toxic insults. In addition to drugs and GSH conjugates, MRP1 exports GSH and GSH disulfide, and might thus have a role in cellular responses to oxidative stress. The transport of several drugs and conjugated organic anions by MRP1 requires the presence of GSH, but it is not well understood how GSH (and its analogues) enhances transport. Site-directed mutagenesis studies and biophysical analyses have provided important insights into the structural determinants of MRP1 that influence GSH and GSH conjugate binding and transport.
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No. Sentence Comment
59 Also indicated are the predicted locations of the amino acid residues identified by site-directed mutagenesis studies to be selectively important for GSH conjugation (LTC4) and/or GSH transport [TM6-Lys332, TM6-His335, TM9-Pro478 (P478A), TM11-Phe594 (F594Y), TM15-Arg1138 (R1138K), CL-Tyr1189, Tyr1190 (Y1189A/S, Y1190A/S) and TM16-Glu1204 (E1204D)] [33,38,40,42,43,75,76].
X
ABCC9 p.Phe594Tyr 16820223:59:252
status: NEW