ABCC1 p.Lys540Glu
| Predicted by SNAP2: | A: D (71%), C: D (71%), D: D (91%), E: D (85%), F: D (75%), G: D (80%), H: D (75%), I: D (71%), L: D (59%), M: D (63%), N: D (80%), P: D (85%), Q: D (71%), R: N (87%), S: D (75%), T: D (66%), V: D (71%), W: D (80%), Y: D (80%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, L: D, M: D, N: D, P: D, Q: D, R: N, S: D, T: D, V: D, W: D, Y: D, |
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[hide] Sulfadiazine resistance in Toxoplasma gondii: no i... Parasite. 2013;20:19. doi: 10.1051/parasite/2013020. Epub 2013 May 27. Doliwa C, Escotte-Binet S, Aubert D, Sauvage V, Velard F, Schmid A, Villena I
Sulfadiazine resistance in Toxoplasma gondii: no involvement of overexpression or polymorphisms in genes of therapeutic targets and ABC transporters.
Parasite. 2013;20:19. doi: 10.1051/parasite/2013020. Epub 2013 May 27., [PMID:23707894]
Abstract [show]
Several treatment failures have been reported for the treatment of toxoplasmic encephalitis, chorioretinitis, and congenital toxoplasmosis. Recently we found three Toxoplasma gondii strains naturally resistant to sulfadiazine and we developed in vitro two sulfadiazine resistant strains, RH-R(SDZ) and ME-49-R(SDZ), by gradual pressure. In Plasmodium, common mechanisms of drug resistance involve, among others, mutations and/or amplification within genes encoding the therapeutic targets dhps and dhfr and/or the ABC transporter genes family. To identify genotypic and/or phenotypic markers of resistance in T. gondii, we sequenced and analyzed the expression levels of therapeutic targets dhps and dhfr, three ABC genes, two Pgp, TgABC.B1 and TgABC.B2, and one MRP, TgABC.C1, on sensitive strains compared to sulfadiazine resistant strains. Neither polymorphism nor overexpression was identified. Contrary to Plasmodium, in which mutations and/or overexpression within gene targets and ABC transporters are involved in antimalarial resistance, T. gondii sulfadiazine resistance is not related to these toxoplasmic genes studied.
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No. Sentence Comment
28 Resistance to sulfonamides and sulfones has been demonstrated to result from mutations within DHPS, such as amino acid changes at five positions (S436A/F, A437G, K540E, A581G, A613/T) [2].
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ABCC1 p.Lys540Glu 23707894:28:162
status: NEW