PMID: 20496145

Tapaninen T, Neuvonen PJ, Niemi M
Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren.
Eur J Clin Pharmacol. 2010 Sep;66(9):865-70. Epub 2010 May 23., [PubMed]
Sentences
No. Mutations Sentence Comment
27 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 20496145:27:167
status: NEW
view ABCB1 p.Ser400Asn details
 To minimize variability in aliskiren pharmacokinetics due to other genetic variants, all subjects were genotyped for the functionally significant ABCB1 c.1199G > A (p.Ser400Asn; rs2229109) [17] and CYP3A5*3 (g.6986A>G; rs776746) [26] alleles and only noncarriers of the ABCB1 c.1199A and CYP3A5 g.6986A (CYP3A5 expressor) alleles were recruited. Login to comment