PMID: 15499174

Ozawa S, Soyama A, Saeki M, Fukushima-Uesaka H, Itoda M, Koyano S, Sai K, Ohno Y, Saito Y, Sawada J
Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1.
Drug Metab Pharmacokinet. 2004 Apr;19(2):83-95., [PubMed]
Sentences
No. Mutations Sentence Comment
85 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 15499174:85:224
status: NEW
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ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 15499174:85:127
status: NEW
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ABCB1 p.Ser1141Thr
X
ABCB1 p.Ser1141Thr 15499174:85:502
status: NEW
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ABCB1 p.Pro1051Ala
X
ABCB1 p.Pro1051Ala 15499174:85:438
status: NEW
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ABCB1 p.Arg669Cys
X
ABCB1 p.Arg669Cys 15499174:85:290
status: NEW
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ABCB1 p.Thr1256Lys
X
ABCB1 p.Thr1256Lys 15499174:85:566
status: NEW
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ABCB1 p.Leu662Arg
X
ABCB1 p.Leu662Arg 15499174:85:259
status: NEW
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ABCB1 p.Val1251Ile
X
ABCB1 p.Val1251Ile 15499174:85:534
status: NEW
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ABCB1 p.Ile849Met
X
ABCB1 p.Ile849Met 15499174:85:321
status: NEW
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ABCB1 p.Met89Thr
X
ABCB1 p.Met89Thr 15499174:85:164
status: NEW
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ABCB1 p.Trp1108Arg
X
ABCB1 p.Trp1108Arg 15499174:85:470
status: NEW
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ABCB1 p.Ile261Val
X
ABCB1 p.Ile261Val 15499174:85:193
status: NEW
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Ethnic diŠerences in nonsynonymous SNPs of ABCB1W MDR1 cDNA positiona Position and amino acid change C AA AS J 61AÀG N21D 0.080 0.025 0.017 0 266TÀC M89T 0.005 0 0 0 781AÀG I261V 0 0.015 0 0 1199GÀA S400N 0.025 0.010 0 0 1985TÀG L662R 0.005 0 0 0 2005CÀT R669C 0 0.010 0 0 2547AÀG I849M 0.005 0 0 0 2677GÀT A893S 0.464 0.100 0.450 0.403 2677GÀA A893T 0.036 0.005 0.067 0.200 3151CÀG P1051A 0 0.005 0 0 3322TÀC W1108R 0 0.005 0 0 3421TÀA S1141T 0 0.111 0 0 3751GÀA V1251I 0 0 0 0.010 3767CÀA T1256K 0.005 0 0 0 C, 100 Caucasians; AA, 100 African-Americans; AS, 30 Asians; J, 145 Japanese (our study 116) ). Login to comment