PMID: 24621983

Dessilly G, Elens L, Panin N, Capron A, Decottignies A, Demoulin JB, Haufroid V
ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines.
PLoS One. 2014 Mar 12;9(3):e91555. doi: 10.1371/journal.pone.0091555. eCollection 2014., [PubMed]
Sentences
No. Mutations Sentence Comment
9 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 24621983:9:61
status: NEW
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 This observation indicates that the amino-acid substitution (Ser400Asn) encoded by the 1199A allele drastically decreases the ability of ABCB1 to drive the efflux of tacrolimus in a substrate-specific manner, in agreement with our previously published clinical data. Login to comment 149 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 24621983:149:155
status: NEW
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 Overexpression of the 1199A variant allele had no effect on Tac accumulation when compared to control cell lines (p.0.05), suggesting that substitution of serine 400 for asparagine strongly reduces ABCB1-mediated Tac efflux in HEK293 and K562 cell lines. Login to comment 206 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 24621983:206:146
status: NEW
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 The differential activity of ABCB1 1199G.A SNP towards Rh123, doxorubicin, vinblastine, Tac and CsA could be explained by the fact that the ABCB1 Ser400Asn substitution is located in a cytoplasmic loop involved in substrate recognition. Login to comment 279 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 24621983:279:104
status: NEW
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 Neoplasma 56: 202-207. 13. Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ (2009) MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Login to comment