PMID: 25881102

Lambrechts S, Lambrechts D, Despierre E, Van Nieuwenhuysen E, Smeets D, Debruyne PR, Renard V, Vroman P, Luyten D, Neven P, Amant F, Leunen K, Vergote I
Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer.
BMC Pharmacol Toxicol. 2015 Feb 27;16:2. doi: 10.1186/s40360-015-0001-5., [PubMed]
Sentences
No. Mutations Sentence Comment
79 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 25881102:79:21
status: NEW
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 rs2229109,c.1199G>A, Ser400Asn Variant allele carriers: correlation with in vitro resistance to paclitaxel [22]. Login to comment 111 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 25881102:111:63
status: NEW
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ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 25881102:111:95
status: NEW
view ABCC2 p.Val417Ile details
ABCC2 p.Lys329Arg
X
ABCC2 p.Lys329Arg 25881102:111:195
status: NEW
view ABCC2 p.Lys329Arg details
 The following 7 genetic variants failed genotyping: rs2032582 (Ser893Ala in ABCB1), rs2273697 (Val417Ile in ABCC2), rs1058930 (Ile194Met in CYP2C8), rs11572080 (Arg69Lyes in CYP2C8), rs10509681 (Lys329Arg in CYP2C8), rs12721627 (Thr185Ser in CYP3A4), rs25487 (Gln398Arg in XRCC1). Login to comment