PMID: 19123050

Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ
MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents.
Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. Epub 2009 Jan 4., [PubMed]
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No. Mutations Sentence Comment
0 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 19123050:0:75
status: NEW
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 DOI 10.1007/s00280-008-0906-4 123 SHORT COMMUNICATION MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents Erica L. Woodahl · Matthew H. Crouthamel · Tot Bui · Danny D. Shen · Rodney J. Y. Ho Received: 11 August 2008 / Accepted: 14 December 2008 / Published online: 4 January 2009 (c) Springer-Verlag 2009 Abstract Purpose P-glycoprotein (P-gp), encoded by MDR1 (or ABCB1), is important in anticancer drug delivery and resistance. Login to comment 18 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 19123050:18:163
status: NEW
view ABCB1 p.Ser400Asn details
 The model for this recombinant cell expression system was expression of the MDR1 G1199A SNP, which results in a serine to asparagine transition at amino acid 400 (Ser400Asn) in a cytoplasmic domain of P-gp (allelic frequency »5.5% in Caucasians) [3, 4]. Login to comment