PMID: 12235446

Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK
Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.
Clin Pharmacol Ther. 2002 Sep;72(3):256-64., [PubMed]
Sentences
No. Mutations Sentence Comment
38 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 12235446:38:258
status: NEW
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ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 12235446:38:199
status: NEW
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ABCB1 p.Phe103Leu
X
ABCB1 p.Phe103Leu 12235446:38:217
status: NEW
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 MDR1 genotyping The following 10 most frequent or putatively functional single nucleotide polymorphisms of the MDR1 gene were identified as described recently: exon 2 G-1A, A61G (amino acid exchange Asn21Asp), T307C (Phe103Leu), exon 6 Cϩ139T, G1199A (Ser400Asn), C1236T, exon 17 T-76A, G2677T/A (Ala893Ser/Thr), and C3435T.18 In brief, the deoxyribonucleic acid (DNA) of venous blood was extracted by use of a standard phenol-chloroform procedure. Login to comment 111 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 12235446:111:139
status: NEW
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 However, there was a significant trend toward higher intestinal MDR1 mRNA but not protein levels in subjects with the polymorphism G2677T (Ala893Ser) in exon 21, which has been shown to have an allelic frequency of 41.6% in German white subjects. Login to comment