PMID: 17301692

Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lonning PE, Borresen-Dale AL, Kristensen VN
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer.
Pharmacogenet Genomics. 2007 Feb;17(2):127-36., [PubMed]
Sentences
No. Mutations Sentence Comment
5 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 17301692:5:135
status: NEW
view ABCB1 p.Ser400Asn details
 Results Chi-square analyses revealed a significant association between TP53 mutation status and both the GA genotype of ABCB1 exon 11 (Ser400Asn) and the GG genotype of GSTP1 (Ile105Val; P<0.01 and P<0.05, respectively). Login to comment 164 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 17301692:164:37
status: NEW
view ABCB1 p.Ser400Asn details
 The polymorphism in exon 11 replaces Ser-400 to asparagine, thereby changing the size of the side chain of the protein and generating a new phosphorylation site. Login to comment