PMID: 25860377

Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.
Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1., [PubMed]
Sentences
No. Mutations Sentence Comment
67 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 25860377:67:164
status: NEW
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ABCB1 p.Arg669Cys
X
ABCB1 p.Arg669Cys 25860377:67:230
status: NEW
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ABCB1 p.Leu662Arg
X
ABCB1 p.Leu662Arg 25860377:67:199
status: NEW
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ABCB1 p.Val1251Ile
X
ABCB1 p.Val1251Ile 25860377:67:296
status: NEW
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ABCB1 p.Met89Thr
X
ABCB1 p.Met89Thr 25860377:67:131
status: NEW
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Only a few reports have described the functional consequences of rare variants in cell models, e.g. variants 266T[C (rs35810889, p.M89T), 1199G[A/T/C (rs2229109, p.S400N/I/T), 1985T[G (rs35657960, p.L662R), 2005C[T (rs35023033, p.R669C), 3322T[C (rs35730308, p.T1108R) and 3751G[A (rs28364274, p.V1251I) [50-52]. Login to comment