PMID: 19819348

Benish RL, Rodriguez B, Zimmerman PA, Mehlotra RK
Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations.
Infect Genet Evol. 2010 Jan;10(1):60-7. Epub 2009 Oct 9., [PubMed]
Sentences
No. Mutations Sentence Comment
155 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 19819348:155:177
status: NEW
view ABCB1 p.Ser400Asn details
ABCB1 p.Ser1141Thr
X
ABCB1 p.Ser1141Thr 19819348:155:265
status: NEW
view ABCB1 p.Ser1141Thr details
ABCB1 p.Gly191Arg
X
ABCB1 p.Gly191Arg 19819348:155:220
status: NEW
view ABCB1 p.Gly191Arg details
 Thus, it is important to determine whether these interethnic genetic differences in MDR1, together with other potentially significant polymorphisms in the MDR1 coding, 1199G>A (Ser400Asn) (Woodahl et al., 2005), 571G>A (Gly191Arg) (Yang et al., 2008), and 3421T>A (Ser1141Thr) (Kroetz et al., 2003), as well as regulatory regions (Taniguchi et al., 2003; Loeuillet et al., 2007), are associated with different outcomes of protease inhibitor-based HIV/AIDS treatment. Login to comment