PMID: 19401306

Hamidovic A, Hahn K, Kolesar J
Clinical significance of ABCB1 genotyping in oncology.
J Oncol Pharm Pract. 2010 Mar;16(1):39-44. Epub 2009 Apr 28., [PubMed]
Sentences
No. Mutations Sentence Comment
39 ABCB1 p.Ser400Asn
X
ABCB1 p.Ser400Asn 19401306:39:725
status: NEW
view ABCB1 p.Ser400Asn details
 Pgp substrates clinically relevant to oncology Anti-cancer agents6,9,13-16 Actinomycin D Mithramycin Bisantrene Mitomycin C Colchicine Mitoxantrone Daunorubicin Paclitaxel Docetaxel Temozolomide Doxorubicin Teniposide Epirubicin Topotecan Etoposide Vinblastine Irinotecan Vincristine Methotrexate Vindesine Examples of MDR-reversal agents in clinical trials15 Verapamil Tamoxifen Cyclosporine A Azidopine Quinidine 40 ABCB1 gene, respectively.11 The SNPs represent the three most frequent ABCB1 SNPs in the Caucasian population and have been shown to be in linkage disequilibrium.19 G2677T/A is at a wobble position which results in an Ala to Ser/Thr change at position 893.20 C1236T is a synonymous mutation resulting in a Ser to Asn change at position 400.21 C3435T is also a synonymous mutation at a wobble position but does not change the amino acid from an Ile at position 1145.22 The allelic frequencies of these three SNPs are highly variable between ethnicities.11,19,22 (Table 2). Login to comment