Mutations at homologous positions to ABCC7 p.Ile332
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Ile332Cys
p.Ile332Lys
|
N
N
?
N
N
?
|
| ABCC1 |
p.Asp578Arg
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Leu327Arg
p.Leu327Cys
p.Ile328Cys
p.Lys329Ala
p.Lys329Cys
p.Lys329Glu
p.Gly330*
p.Gly330Cys
p.Ile331Cys
p.Leu333Ala
p.Leu333Cys
p.Arg334Trp
p.Arg334Leu
p.Arg334Gln
p.Arg334Cys
p.Arg334Ala
p.Arg334His
p.Arg334Glu
p.Arg334Lys
p.Arg334Asp
p.Arg334*
p.Arg334Thr
p.Lys335Glu
p.Lys335Ile
p.Lys335Phe
p.Lys335Ala
p.Lys335Cys
p.Lys335Gln
p.Lys335Asp
p.Lys335Arg
p.Lys335His
p.Ile336Lys
p.Ile336Ala
p.Ile336Cys
p.Ile336Leu
p.Phe337Ser
p.Phe337Ala
p.Phe337Tyr
p.Phe337Cys
p.Phe337Glu
p.Phe337Leu
p.Phe337Trp
p.Phe337Arg
|
D
D
?
N
D
?
N
N
?
N
N
?
D
N
?
D
N
?
-
-
D
D
D
D
D
D
?
N
N
D
N
N
D
D
D
D
D
N
D
N
D
D
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
-
-
D
D
N
D
D
N
?
D
N
?
D
D
?
D
N
?
D
D
?
N
N
?
D
N
?
N
N
?
D
N
?
D
D
D
D
N
?
D
N
?
D
N
?
D
D
?
D
D
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCC1 |
p.Glu573Arg
p.Gln580Ala
p.Thr581Ala
|
N
D
?
D
D
?
D
N
?
|
| ABCC2 |
p.Lys578Ala
|
D
D
?
|
| ABCC6 |
p.Met562Thr
p.Phe568Ser
|
D
D
D
D
D
D
|
| ABCC8 |
p.Lys567Cys
p.Glu568Lys
p.Ser574Gly
|
D
N
?
D
N
?
N
N
?
|
The alignment around the queried position:
ABCC7 296
T
A
N
S
S
-
-
-
D
G
A
I
I
372
ABCC1 539
L
K
S
A
Y
L
S
A
V
G
F
V
F
L
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
I
I
V
Q
A
S
V
S
L
K
R
L
R
617
ABCC2 536
L
L
A
F
S
Q
L
Q
C
V
V
I
F
V
F
Q
L
T
P
V
L
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
I
S
S
M
L
Q
A
V
S
T
E
R
L
E
614
ABCC3 525
L
R
A
Y
L
H
T
T
T
T
F
T
W
M
C
S
P
F
L
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
I
S
N
L
T
Q
A
S
V
S
L
K
R
I
Q
603
ABCC4 310
I
L
R
S
S
C
L
R
G
M
N
L
A
S
F
F
S
A
S
K
I
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
I
V
S
A
I
V
S
I
R
R
I
Q
387
ABCC5 392
L
E
K
A
G
Y
F
Q
S
I
T
V
G
V
A
P
I
V
V
V
I
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
V
K
S
L
S
E
A
S
V
A
V
D
R
F
K
468
ABCC6 525
L
R
T
S
G
L
L
F
S
V
L
V
S
F
Q
V
S
T
F
L
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
I
H
S
L
V
Q
A
R
V
S
F
D
L
V
602
ABCC8 533
R
A
A
I
Y
T
S
I
S
I
F
M
N
T
A
I
I
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
V
S
T
K
A
L
V
S
Q
K
L
S
611
ABCC9 529
L
K
T
F
A
L
Y
T
S
L
S
I
F
M
N
A
A
I
P
I
A
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
V
R
A
V
K
A
I
I
S
V
Q
K
L
N
606
ABCC10 496
L
R
V
I
K
Y
L
D
A
A
C
V
Y
L
W
A
A
L
P
V
V
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
I
N
G
L
L
E
A
K
V
S
L
D
R
I
Q
572
ABCC11 376
L
E
K
C
G
L
V
Q
S
L
T
S
I
T
L
F
I
I
P
T
V
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
V
K
G
L
T
N
S
K
S
A
V
M
R
F
K
452
ABCC12 336
L
E
K
A
G
F
V
Q
S
G
N
S
A
L
A
P
I
V
S
T
I
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
I
K
A
M
A
E
A
N
V
S
L
R
R
M
K
412