Mutations at homologous positions to ABCC7 p.Lys335
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Lys335Glu
p.Lys335Ile
p.Lys335Phe
p.Lys335Ala
p.Lys335Cys
p.Lys335Gln
p.Lys335Asp
p.Lys335Arg
p.Lys335His
|
D
N
?
D
N
?
D
D
?
D
N
?
D
D
?
N
N
?
D
N
?
N
N
?
D
N
?
|
| ABCC1 |
p.Thr581Ala
|
D
N
?
|
| ABCC2 |
p.Lys578Ala
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Gly330*
p.Gly330Cys
p.Ile331Cys
p.Ile332Cys
p.Ile332Lys
p.Leu333Ala
p.Leu333Cys
p.Arg334Trp
p.Arg334Leu
p.Arg334Gln
p.Arg334Cys
p.Arg334Ala
p.Arg334His
p.Arg334Glu
p.Arg334Lys
p.Arg334Asp
p.Arg334*
p.Arg334Thr
p.Ile336Lys
p.Ile336Ala
p.Ile336Cys
p.Ile336Leu
p.Phe337Ser
p.Phe337Ala
p.Phe337Tyr
p.Phe337Cys
p.Phe337Glu
p.Phe337Leu
p.Phe337Trp
p.Phe337Arg
p.Thr338Ile
p.Thr338Ala
p.Thr338Ser
p.Thr338Met
p.Thr338Glu
p.Thr338Gln
p.Thr338Cys
p.Thr338His
p.Thr338Phe
p.Thr338Asn
p.Thr338Val
p.Thr338Lys
p.Thr338Arg
p.Thr339Ala
p.Thr339Val
p.Thr339Cys
p.Thr339Ser
p.Thr339Phe
p.Thr339Tyr
p.Ile340Ala
p.Ile340Cys
p.Ile340Asn
|
-
-
D
D
D
D
D
D
?
N
N
?
N
N
?
N
N
D
N
N
D
D
D
D
D
N
D
N
D
D
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
-
-
D
D
N
D
D
D
D
D
N
?
D
N
?
D
N
?
D
D
?
D
D
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
D
D
N
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
N
?
D
N
?
D
D
?
D
D
?
N
N
?
D
N
?
D
N
?
N
N
?
D
N
?
D
D
?
N
N
?
N
D
?
D
D
?
|
| ABCC1 |
p.Asp578Arg
p.Gln580Ala
p.Ser585Ala
|
D
D
?
D
D
?
D
D
?
|
| ABCC6 |
p.Met562Thr
p.Phe568Ser
|
D
D
D
D
D
D
|
| ABCC8 |
p.Ser574Gly
p.Leu580Phe
|
N
N
?
D
D
?
|
The alignment around the queried position:
ABCC7 299
A
N
S
S
-
-
-
D
G
A
I
I
D
375
ABCC1 542
S
A
Y
L
S
A
V
G
F
V
F
L
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
I
I
V
Q
A
S
V
S
L
K
R
L
R
I
F
L
620
ABCC2 539
F
S
Q
L
Q
C
V
V
I
F
V
F
Q
L
T
P
V
L
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
I
S
S
M
L
Q
A
V
S
T
E
R
L
E
K
Y
L
617
ABCC3 528
A
Y
L
H
T
T
T
T
F
T
W
M
C
S
P
F
L
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
I
S
N
L
T
Q
A
S
V
S
L
K
R
I
Q
Q
F
L
606
ABCC4 313
S
S
C
L
R
G
M
N
L
A
S
F
F
S
A
S
K
I
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
I
V
S
A
I
V
S
I
R
R
I
Q
T
F
L
390
ABCC5 395
A
G
Y
F
Q
S
I
T
V
G
V
A
P
I
V
V
V
I
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
V
K
S
L
S
E
A
S
V
A
V
D
R
F
K
S
L
F
471
ABCC6 528
S
G
L
L
F
S
V
L
V
S
F
Q
V
S
T
F
L
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
I
H
S
L
V
Q
A
R
V
S
F
D
L
V
T
F
L
605
ABCC8 536
A
I
Y
T
S
I
S
I
F
M
N
T
A
I
I
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
V
S
T
K
A
L
V
S
Q
K
L
S
E
F
L
614
ABCC9 532
F
A
L
Y
T
S
L
S
I
F
M
N
A
A
I
P
I
A
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
V
R
A
V
K
A
I
I
S
V
Q
K
L
N
E
F
L
609
ABCC10 499
I
K
Y
L
D
A
A
C
V
Y
L
W
A
A
L
P
V
V
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
I
N
G
L
L
E
A
K
V
S
L
D
R
I
Q
L
F
L
575
ABCC11 379
C
G
L
V
Q
S
L
T
S
I
T
L
F
I
I
P
T
V
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
V
K
G
L
T
N
S
K
S
A
V
M
R
F
K
K
F
F
455
ABCC12 339
A
G
F
V
Q
S
G
N
S
A
L
A
P
I
V
S
T
I
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
I
K
A
M
A
E
A
N
V
S
L
R
R
M
K
K
I
L
415