ABCC7 p.Thr339Cys

Predicted by SNAP2: A: N (57%), C: D (75%), D: D (85%), E: D (91%), F: D (85%), G: D (80%), H: D (71%), I: D (71%), K: D (91%), L: D (75%), M: D (85%), N: D (75%), P: D (85%), Q: D (75%), R: D (91%), S: N (57%), V: D (63%), W: D (91%), Y: D (85%),
Predicted by PROVEAN: A: N, C: N, D: N, E: N, F: N, G: N, H: D, I: N, K: N, L: N, M: N, N: N, P: N, Q: N, R: N, S: N, V: N, W: D, Y: D,

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[hide] Beck EJ, Yang Y, Yaemsiri S, Raghuram V
Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating.
J Biol Chem. 2008 Feb 22;283(8):4957-66. Epub 2007 Dec 3., 2008-02-22 [PMID:18056267] [PubMed]

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[hide] Alexander C, Ivetac A, Liu X, Norimatsu Y, Serrano JR, Landstrom A, Sansom M, Dawson DC
Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.
Biochemistry. 2009 Oct 27;48(42):10078-88., 2009-10-27 [PMID:19754156] [PubMed]

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[hide] Linsdell P, Zheng SX, Hanrahan JW
Non-pore lining amino acid side chains influence anion selectivity of the human CFTR Cl- channel expressed in mammalian cell lines.
J Physiol. 1998 Oct 1;512 ( Pt 1):1-16., 1998-10-01 [PMID:9729613] [PubMed]

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[hide] Sheppard DN, Welsh MJ
Structure and function of the CFTR chloride channel.
Physiol Rev. 1999 Jan;79(1 Suppl):S23-45., [PMID:9922375] [PubMed]

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[hide] Liu X, Dawson DC
Cystic fibrosis transmembrane conductance regulator: temperature-dependent cysteine reactivity suggests different stable conformers of the conduction pathway.
Biochemistry. 2011 Nov 29;50(47):10311-7. Epub 2011 Nov 4., [PMID:22014307] [PubMed]

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[hide] Cheung M, Akabas MH
Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.
Biophys J. 1996 Jun;70(6):2688-95., [PMID:8744306] [PubMed]

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