PMID: 19745014

Kim HJ, Hwang SY, Kim JH, Park HJ, Lee SG, Lee SW, Joo JC, Kim YK
Association between Genetic Polymorphism of Multidrug Resistance 1 Gene and Sasang Constitutions.
Evid Based Complement Alternat Med. 2009 Sep;6 Suppl 1:73-80., [PubMed]
Sentences
No. Mutations Sentence Comment
95 ABCB1 p.Thr1236Cys
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ABCB1 p.Thr1236Cys 19745014:95:120
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 Haplotype frequencies of MDR1 SNPs in Sasang constitutions Haplotypes of MDR1 gene Haplotype frequency in each group P* T1236C G2677T/A C3435T Tae-eumin (n ¼ 51) (%) So-yangin (n ¼ 56) (%) So-eumin (n ¼ 100) (%) Pa /Pb /Pc T T T 24.08 26.47 28.58 0.68/0.68/0.40 C G C 22.44 13.70 23.18 0.09/0.04/0.88 T G C 24.22 15.83 17.14 0.12/0.76/0.14 C A C 13.44 14.46 14.98 0.82/0.90/0.71 T T C 5.24 5.26 4.53 0.99/0.77/0.78 T G T 5.00 6.19 1.72 0.70/0.03/0.10 C T C 2.05 5.39 3.39 0.20/0.39/0.51 T A C 1.25 7.86 1.28 0.02/0.002/0.98 C T T - 4.85 - 0.02/0.001/- T A T - - 2.74 -/0.07/0.32 C G T 1.29 - 2.45 0.22/0.09/0.50 Dash indicates values below 0.01%; a Tae-eumin versus So-yangin; b So-yangin versus So-eumin; c Tae-eumin versus So-eumin; *Values calculated by 2 -test. Table 3. Frequencies of MDR1 C1236T genotype and Sasang constitutions Tae-eumin (n ¼ 51) (%) So-yangin (n ¼ 56) (%) So-eumin (n ¼ 100) (%) P* T/T 17 (33.3) 23 (41.1) 25 (25.0) C/T 28 (54.9) 23 (41.1) 62 (62.0) 0.33a /0.03b /0.55c C/C 6 (11.8) 10 (17.9) 13 (13.0) a Tae-eumin versus So-yangin; b So-yangin versus So-eumin; c Tae-eumin versus So-eumin; *Values calculated by 2 -test. Table 4. Frequencies of MDR1 G2677T/A allele in Sasang constitutions Tae-eumin (n ¼ 102) (%) So-yangin (n ¼ 112) (%) So-eumin (n ¼ 200) (%) P* G 54 (52.9) 40 (35.7) 89 (44.5) 0.04a /0.31b /0.37c T 32 (31.4) 47 (42.0) 73 (36.5) A 16 (15.7) 25 (22.3) 38 (19.0) a Tae-eumin versus So-yangin; b So-yangin versus So-eumin; c Tae-eumin versus So-eumin; *Values calculated by 2 -test. Table 2. Login to comment 129 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 19745014:129:148
status: NEW
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 Table 6. Frequencies of MDR1 haplotypes in Korean compared with other populations Haplotypes of MDR1 gene German Caucasian % Chinese Han % Korean % T1236C G2677T/A C3435T (n ¼ 461) (n ¼ 165) (n ¼ 207) T T T 41.0 33.3 26.5 C G C 37.0 20.1 20.4 T G C 1.0 22.2 18.6 C A C 2.5 11.3 14.5 T T C 2.5 5.6 5.2 T G T 0.5 1.0 3.9 C T C 1.5 1.7 3.4 T A C 0.0 1.2 2.9 C T T 1.0 1.6 1.7 T A T 0.0 0.4 1.6 C G T 12.0 1.2 1.3 C A T 1.0 0.4 0.0 Reference 19 24 This study Particularly as in Sai et al., haplotype 1236T-2677T-3435T showed the highest frequency in Japanese and Koreans. Login to comment