PMID: 16651648

Wong M, Balleine RL, Blair EY, McLachlan AJ, Ackland SP, Garg MB, Evans S, Farlow D, Collins M, Rivory LP, Hoskins JM, Mann GJ, Clarke CL, Gurney H
Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer.
J Clin Oncol. 2006 Jun 1;24(16):2448-55. Epub 2006 May 1., 2006-06-01 [PubMed]
Sentences
No. Mutations Sentence Comment
45 ABCB1 p.Thr1236Cys
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ABCB1 p.Thr1236Cys 16651648:45:411
status: NEW
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 of patients 41 Male 25 Female 16 Age Mean, years 63 Range 43-81 Body-surface area, m2 Mean 1.84 Range 1.41-2.46 Ethnicity White 39 Nonwhite 2 Cancer type Prostate 16 Breast 10 Lung 8 Bladder 3 Others 4 ECOG performance status 0 25 1 15 2 1 Liver metastasis Yes 14 No 25 Unknown 2 Prior chemotherapy Yes 26 No 15 Pretreatment neutrophil count, ϫ10 9 /L (mean Ϯ SD) 5.9 Ϯ 2.8 ABCB1 SNPs Exon 12 T1236C CC 6 CT 23 TT 12 Exon 21 G2677T, A GG 5 GT 24 GA 2 TT 10 Exon 26 C3435T CC 7 CT 23 TT 11 CYP3A5 SNP *1/*3 3 *3/*3 38 Abbreviations: ECOG, Eastern Cooperative Oncology Group; SNP, single nucleotide polymorphism; SD, standard deviation; C, cytosine; T, thymine; G, guanine; A, adenine. Login to comment 80 ABCB1 p.Thr1236Cys
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ABCB1 p.Thr1236Cys 16651648:80:670
status: NEW
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 Association Between Potential Predictors, Vinorelbine Clearance, and Fractional Survival of Neutrophil Postvinorelbine Variable Correlation With Vinorelbine Clearance Correlation With Fractional Survival of Neutrophils Postvinorelbine No. Spearman`s Rho P No. Spearman`s Rho P Age 34 -0.28 .11 38 -0.05 .78 Sex (male/female) 34 .06 38 .02 ECOG (0 to 3) 34 .56 38 .29 Prior chemotherapy (Y/N) 34 .42 38 .64 Liver metastasis (Y/N) 32 .11 36 .28 Body habitus‫ء‬ Body-surface area† 34 0.17 .33 38 0.48 Ͻ .01 Height 34 0.25 .16 38 0.41 .01 Pretreatment platelet count 32 -0.16 .39 N/A‡ Genotype CYP3A5*1/*3 34 .25 38 .50 ABCB1 exon 12 T1236C 34 .78 38 .44 exon 21 G2677T, A 34 .82 38 .54 exon 26 C3435T 34 .25 38 .69 Liver function tests Aspartate transaminase 33 -0.23 .20 37 -0.19 .26 Alanine transaminase 34 -0.16 .38 38 -0.03 .87 Alkaline phosphatase 34 0.05 .78 38 -0.09 .60 Serum albumin 34 -0.12 .51 38 0.07 .67 INR 28 -0.21 .27 30 0.06 .74 Bile acids 18 0.06 .81 18 -0.10 .68 Clearance indicators Creatinine clearance§ 34 0.34 .05 38 0.39 .02 Hepatic 99m Tc-MIBI clearance (kH ϫ liver volume) 33 0.32 .07 37 0.28 .09 Midazolam clearance 34 -0.06 .73 37 0.12 .47 Abbreviations: ECOG, Eastern Cooperative Oncology Group; Y, yes; N, no; INR, international normalized ratio; 99m Tc-MIBI, technetium labeled sestamibi; kH, elimination rate constant. Login to comment