PMID: 20204543

Ni LN, Li JY, Miao KR, Qiao C, Zhang SJ, Qiu HR, Qian SX
Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemia.
Med Oncol. 2011 Mar;28(1):265-9. Epub 2010 Mar 4., [PubMed]
Sentences
No. Mutations Sentence Comment
3 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 20204543:3:25
status: NEW
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 We investigated the MDR1 T1236C, G 2677T/A, and C3435T polymorphism in 52 patients with chronic myeloid leukemia treated with imatinib. Login to comment 17 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 20204543:17:9
status: NEW
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 The SNPs T1236C, G 2677T/A, and C3435T are the most common variants in the coding region of ABCB1 [3]. Login to comment 21 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 20204543:21:47
status: NEW
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 Therefore, it is important that we analyze the T1236C, G2677T/A, and C3435T most relevant SNPs to identify genetic variants underlying susceptibility to imatinib efficacy in Chinese. Login to comment