ABCMdb

PMID: 15901749

Nakajima M, Fujiki Y, Kyo S, Kanaya T, Nakamura M, Maida Y, Tanaka M, Inoue M, Yokoi T
Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1.
J Clin Pharmacol. 2005 Jun;45(6):674-82., [PubMed]

Sentences

No. Mutations Sentence Comment

106 ABCB1 p.Thr1236Cys Table II Genotype of CYP3A4 and MDR1 Genes in Each Patient MDR1 Patient CYP3A4*16 T-129C T1236C G2677T/A C3435T 1 C/G T/T T/T G/G C/C 2 C/G T/T T/T G/T C/C 3 C/C T/T T/T G/T C/C 4 C/C T/T T/T G/A C/C 5 C/C T/C C/C G/A C/C 6 C/C T/T T/T G/T C/T 7 C/C T/T T/T G/T C/T 8 C/C T/T T/T G/T C/T 9 C/C T/T T/T G/T C/T 10 C/C T/T T/T G/T C/T 11 C/C T/T T/T G/T C/T 12 C/C T/T T/T G/T C/T 13 C/C T/T T/T G/T C/T 14 C/C T/T T/T T/A C/T 15 C/C T/T T/T T/A C/T 16 C/C T/T T/C T/A C/T 17 C/C T/T T/T T/T C/T 18 C/C T/T T/T T/T T/T 19 C/C T/T T/T T/T T/T 20 C/C T/T T/T T/T T/T 21 C/C T/T T/T T/T T/T 22 C/C T/T T/T T/T T/T 23 C/C T/T T/C G/T T/T Shading indicates nucleotides in mutant type. Login to comment 141 ABCB1 p.Thr1236Cys A number of SNPs have been identified in the human MDR1 gene.19,21,33,34 Of these SNPs, T-129C (noncoding), T1236C (Gly412Gly, wobble), G2677T/A (Ala893Ser/Thr), and C3435T (Ile1145Ile, wobble) are associated with alterations in the expression of P-glycoprotein and pharmacokinetic profiles of certain clinically used drugs.19,21,34 The present study showed an apparent association between the presence of 3435T allele and increased AUC of 3'-p-hydroxypaclitaxel. Login to comment