ABCMdb

PMID: 14501869

Kuzuya T, Kobayashi T, Moriyama N, Nagasaka T, Yokoyama I, Uchida K, Nakao A, Nabeshima T
Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients.
Transplantation. 2003 Sep 15;76(5):865-8., 2003-09-15 [PubMed]

Sentences

No. Mutations Sentence Comment

56 ABCB1 p.Thr1236Cys The genotypes of MDR1 (exon 1b, T-129C; exon 12, T1236C; exon 21, G2677[T/A]; and exon 26, C3435T) were identified by a polymerase chain reaction, restriction fragment length polymorphism analysis as described previously (11). Login to comment 65 ABCB1 p.Thr1236Cys T1236C, G2677T, G2677A, and C3435T mutations occurred with variant allele frequencies of 42.3%, 39.7%, 23.7%, and 41.2%, respectively. Login to comment 84 ABCB1 p.Thr1236Cys Therefore, we tried to compare the effects of MDR1 polymorphisms on CsA AUC0 -2/dose/kg again without amlodipine treatment, but there was still no significant difference (T-129C, Pϭ0.202; T1236C, Pϭ0.447; G2677T/A, Pϭ0.765; and C3435T, Pϭ0.877). Login to comment 97 ABCB1 p.Thr1236Cys MDR1 genetic variants in 97 kidney transplant recipients Position Region Genotype Allele frequency (%) W/W W/M M/M W M T-129C Exon 1b 88 9 95.4 4.6 T1236C Exon 12 30 52 15 57.7 42.3 G2677T Exon 21 12(G/G) 33 (G/T) 11 (T/T) 36.6 39.7(T) G2677A Exon 21 14 (G/A) 5 (A/A) 23.7(A) G2677A 22 (T/A) C3435T Exon 26 33 48 16 58.8 41.2 TABLE 3. Login to comment 98 ABCB1 p.Thr1236Cys P values between SNP and AUC0-2/dose/kg AUC0-2/dose/kg 752.8Ϯ194.1a T-129C 0.279 T1236C 0.868 G2677T/A 0.911 C3435T 0.973 a MeanϮSD. FIGURE 2. Login to comment