PMID: 12189368

Kurata Y, Ieiri I, Kimura M, Morita T, Irie S, Urae A, Ohdo S, Ohtani H, Sawada Y, Higuchi S, Otsubo K
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.
Clin Pharmacol Ther. 2002 Aug;72(2):209-19., [PubMed]
Sentences
No. Mutations Sentence Comment
57 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 12189368:57:317
status: NEW
view ABCB1 p.Thr1236Cys details
ABCB1 p.Met986Val
X
ABCB1 p.Met986Val 12189368:57:494
status: NEW
view ABCB1 p.Met986Val details
 1 5 14 15 16 2 7 9 11 12 3 4 6 10 13 5Ј-Flanking region A-41aG Noncoding A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A G/G Exon 1a C-145G Noncoding C/C C/C C/C C/C C/C C/C C/C C/C C/C C/C C/C C/C C/C C/C C/C Exon 1b T-129C Noncoding T/T T/T T/T T/T T/T T/T T/T T/T T/T T/T T/T T/T T/T T/T T/C Exon 12 T1236C Gly412Gly C/C C/C T/T T/T T/C T/T C/C T/T T/T T/C T/T T/T T/T T/T T/T Exon 21 G2677T Ala893Ser G/G G/G G/G G/G G/G G/T G/T G/T G/T G/T T/T T/T T/T T/T T/T Exon 24 A2956G Met986Val A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A A/A Exon 26 C3435T Ile1145I1e C/C C/C C/C C/C C/C C/T C/T C/T C/T C/T T/T T/T T/T T/T T/T Exon 28 G4030C Noncoding G/G G/G G/G G/G G/G G/G G/G G/G G/G G/G G/G G/G G/G G/G G/G Exon 28 A4036G Noncoding A/G A/A A/G A/A A/A A/G A/A G/G A/A A/A A/G A/G A/A A/G A/G Genotypic classification G/G2677C/C3435 G/T2677C/T3435 T/T2677T/T3435 Fig 1. Login to comment