ABCMdb

PMID: 12172212

Tang K, Ngoi SM, Gwee PC, Chua JM, Lee EJ, Chong SS, Lee CG
Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations.
Pharmacogenetics. 2002 Aug;12(6):437-50., [PubMed]

Sentences

No. Mutations Sentence Comment

18 ABCB1 p.Gly185Val ABCB1 p.Phe983Ala It has been reported that cells carrying the F983A change exhibit increased resistance to reversal by flupentixol but not other drugs [6], while cells carrying the G185V change have increased resistance to colchicine but not other drugs [7,8]. Login to comment 31 ABCB1 p.Thr1236Cys To date, detailed linkage disequilibrium analysis of the different polymorphisms of the MDR1 gene has not been documented, although a recent publication by Kim et al. [19] reported co-segregation of exon 26 3435T with the T allele of the non-synonymous exon 21 SNP G2677T (exon 21 2677G.T), resulting in an A893S amino acid change, and the T allele of the synonymous exon 12 SNP T1236C (exon 12 1236C.T) in Caucasians. Login to comment 101 ABCB1 p.Asn21Asp The previously reported exon 2 61A.G polymorphism, which changes the codon from Asn to Asp at amino acid position 21 in the MDR1 protein, has a minor G allele frequency of 11.2% in German Caucasians [11]. Login to comment