ABCMdb

PMID: 16821592

Obata H, Yahata T, Quan J, Sekine M, Tanaka K
Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer.
Anticancer Res. 2006 May-Jun;26(3B):2227-32., [PubMed]

Sentences

No. Mutations Sentence Comment

84 ABCC1 p.Arg723Gln ABCB1 p.Thr1236Cys ABCB1 p.Gly1249Ala Gene Nucleic acid Amino acid Allele frequencies Allele frequencies location change substitution (major alleles) (major alleles) in this study in other subject* MDR1 Promotor 1 T/C - 0.908 - Promotor 2 A-41aG - 0.883 0.927 exon-12 T1236C Gly412Gly 0.633 0.615 exon-26 G/A IIe1144IIe 0.500 - exon-28 A/G - 0.742 - MRP1 exon-8 T825C Val275Val 0.600 0.625 exon-9 T1062C Asn354Asn 0.567 0.646 exon-13 T1684C Leu562Leu 0.750 0.802 exon-16 C2007T Pro669Pro 0.950 0.917 exon-17 G2168A Arg723Gln 0.917 0.927 exon-28 G4002A Ser1334Ser 0.883 0.844 MRP2 Promotor C-24T - 0.867 - exon-10 G1249A Val417IIe 0.925 0.875 exon-28 C3972T IIe1324IIe 0.758 0.781 *Ito S. et al. Login to comment 130 ABCC1 p.Arg723Gln On the basis of these reports, the significant correlation with the response to chemotherapy found in this study seems to suggest the possibility that exon-17 G2168A (Arg723Gln) polymorphism is relevant to the change in the function of MRP1, although the precise mechanism requires further examination. Login to comment