PMID: 15637529

Wong M, Evans S, Rivory LP, Hoskins JM, Mann GJ, Farlow D, Clarke CL, Balleine RL, Gurney H
Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer.
Clin Pharmacol Ther. 2005 Jan;77(1):33-42., [PubMed]
Sentences
No. Mutations Sentence Comment
136 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 15637529:136:294
status: NEW
view ABCB1 p.Thr1236Cys details
 Frequency of ABCB1 variants ABCB1 locus Genotype Actual frequency (%) Predicted frequency (%) (Hardy-Weinberg equilibrium) ␹2 (P value) Exon 12 CC 17 17 0.021 (.885) CT 48 48 TT 35 35 Exon 21 GG 17 20 3.125 (.373) GT 52 48 GA 3 1 TT 28 28 Exon 26 CC 17 19 0.597 (.440) CT 53 49 TT 30 32 T1236C in exon 12, G2677T/A in exon 21, and C3435T polymorphisms in exon 26 of ABCB1 were detected by polymerase chain reaction-restriction fragment length polymorphism. Login to comment