ABCMdb

PMID: 16803472

Yamaguchi H, Hishinuma T, Endo N, Tsukamoto H, Kishikawa Y, Sato M, Murai Y, Hiratsuka M, Ito K, Okamura C, Yaegashi N, Suzuki N, Tomioka Y, Goto J
Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer.
Int J Gynecol Cancer. 2006 May-Jun;16(3):979-85., [PubMed]

Sentences

No. Mutations Sentence Comment

11 ABCB1 p.Thr1236Cys ABCB1 T-129C, T1236C, and G2677(A,T), however, was associated with lower area under the plasma concentration-time curve (AUC) of paclitaxel. Login to comment 41 ABCB1 p.Thr1236Cys CYP2C8 A805T (CYP2C8*2), G416A/A1196G (CYP2C8*3), and C792G (CYP2C8*4), and ABCB1 T-129C, T1236C, G2677(A,T), and C3435T were genotyped by polymerase chain reaction (PCR)-restriction enzyme fragment length polymorphism as previously described with minor modification(15-17) . Login to comment 68 ABCB1 p.Thr1236Cys CYP2C8, CYP3A5, ABCB1, and PXR genotypes in 13 patientsa Patient number CYP2C8 CYP3A5 ABCB1 PXR A6986G T-129C T1236C G2677 (A,T) C3435T C-25385T 1 *1/*1 A/G T/T T/T G/T C/T C/C 2 *1/*1 A/G T/T T/C A/T C/C C/C 3 *1/*1 G/G T/T T/C G/G C/T C/C 4 *1/*1 A/G T/T T/T T/T T/T C/T 5 *1/*1 A/A T/T T/T G/T C/T T/T 6 *1/*1 A/G T/T T/T G/G C/C C/C 7 *1/*1 G/G T/T T/C G/G C/C C/C 8 *1/*1 G/G T/T T/T G/T C/T C/T 9 *1/*1 A/G T/T T/T G/T C/T C/C 10 *1/*1 G/G T/T T/T G/T C/T C/C 11 *1/*1 A/G T/T T/C G/T C/C C/T 12 *1/*1 G/G T/C C/C A/A C/C C/T 13 *1/*1 G/G T/T T/C G/T C/T C/C a The most common (wild-type) CYP2C8 allele was CYP2C8*1. than the frequencies of 0.39 and 0.32 observed for Caucasian and African American populations, respectively(21) . Login to comment 80 ABCB1 p.Thr1236Cys Although the differences were not statistically significant, ABCB1 T1236C tended to be associated with lower paclitaxel AUC (11.4 Æ 2.32, 9.62 Æ 1.48, and 5.73 lgÁh/mL for 1236T/T, T/C, and C/C genotypes [n ¼ 7, 5, and 1], respectively). Login to comment 87 ABCB1 p.Thr1236Cys As ABCB1 T-129C, T1236C, and G2677(A,T) were associated with lower paclitaxel AUC (Fig. 2), we examined the relationships between total ABCB1 mutant allele numbers and either paclitaxel AUC or CLtot in 13 patients. Login to comment 110 ABCB1 p.Thr1236Cys ABCB1 T1236C is associated with significantly increased exposure to irinotecan and the active metabolite SN-38(26) . Login to comment