PMID: 12352921

Yamauchi A, Ieiri I, Kataoka Y, Tanabe M, Nishizaki T, Oishi R, Higuchi S, Otsubo K, Sugimachi K
Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene.
Transplantation. 2002 Aug 27;74(4):571-2., 2002-08-27 [PubMed]
Sentences
No. Mutations Sentence Comment
47 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 12352921:47:92
status: NEW
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 The independent variables were as follows: the eight polymorphisms (A-41aG, C-145G, T-129C, T1236C, G2677[A,T], C3435T, and A4036G) and the number of mutations, age, graft weight, ratio of graft weight to recipient`s standard liver volume, tacrolimus trough concentration, hematocrit, aspartate aminotransferase (AST), alanine aminotransferase, and serum albumin concentration (thought to affect the tacrolimus distribution in the brain). Login to comment 61 ABCB1 p.Thr1236Cys
X
ABCB1 p.Thr1236Cys 12352921:61:387
status: NEW
view ABCB1 p.Thr1236Cys details
 Position, sequence, and frequencies of ABCB1 mutations in Japanese living-related donor liver transplantation patients ABCB1 exon/ position Region Nucleotide sequence Effect Genotype Allele frequency Wild type Mutation w/w w/m m/m w m A-41aG UTR cccaAtgat cccaGtgat 11 5 1 0.79 0.21 C-145G Exon 1a gaagCctag gaagGctag 15 2 0 0.94 0.06 T-129C Exon 1b cgagTagcg cgagCagcg 12 3 2 0.79 0.21 T1236C Exon 12 agggTctga agggCctga 7 7 3 0.62 0.38 G2677A Exon 21 aggtGctgg aggtActgg Ala893Thr 6 G/Aϭ2 A/Aϭ0 0.59 0.09 G2677T Exon 21 aggtGctgg aggtTctgg Ala893Ser G/Tϭ6 T/Tϭ2 0.32 A/Tϭ1 C3435T Exon 26 agatCgtga agatTgtga 4 10 3 0.53 0.47 A4036G Exon 28 aatcAtagt aatcGtagt 7 7 3 0.62 0.38 UTR, untranslated region; w, wild type; m, mutation. Login to comment