Mutations at homologous positions to ABCC8 p.Ala161
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC8 |
p.Ala161Cys
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC8 |
p.His160Ala
p.Ile162Cys
p.Ser165Leu
|
N
N
?
N
N
?
N
D
?
|
| ABCC4 |
p.Leu18Ile
|
N
N
?
|
| ABCC6 |
p.Gln154Arg
|
N
N
?
|
| ABCC7 |
p.Pro5Leu
p.Val11Ile
p.Val11Cys
p.Ser13Phe
p.Ser13Ala
p.Ser13Tyr
p.Ser13Cys
p.Lys14*
p.Lys14Arg
p.Leu15Pro
|
D
D
D
N
N
?
N
N
?
D
D
D
N
?
D
D
?
D
D
?
-
-
N
N
?
D
D
?
|
The alignment around the queried position:
ABCC8 122
V
Y
Y
N
I
T
S
N
P
K
I
A
L
L
V
Y
L
F
I
T
K
T
K
F
V
K
F
L
D
G
F
Q
L
L
T
G
L
L
I
L
M
L
L
V
E
V
I
V
R
I
F
F
201
ABCC1 122
F
L
I
Q
L
E
R
R
K
G
V
Q
-
S
S
G
I
M
L
F
L
V
A
L
V
L
A
L
R
S
K
I
M
T
A
L
K
E
D
A
Q
V
D
L
F
R
D
I
T
F
Y
V
Y
F
S
L
L
L
I
Q
L
V
L
S
F
S
D
R
S
L
F
E
200
ABCC2 115
L
L
I
Q
Y
S
W
C
V
Q
K
N
S
W
F
L
S
L
F
W
I
L
S
I
L
C
G
T
F
Q
F
Q
T
-
L
I
R
T
L
L
Q
G
D
N
S
N
L
A
Y
S
C
L
F
F
I
S
Y
G
F
Q
I
L
I
L
I
F
S
A
F
E
-
-
-
-
-
-
-
187
ABCC3 121
L
L
I
Q
Y
E
R
L
Q
G
V
Q
-
S
S
G
V
L
I
I
F
W
F
L
C
V
V
C
A
I
V
P
F
R
S
K
I
L
L
A
K
A
E
G
E
I
S
P
F
R
F
T
T
F
Y
I
H
F
A
L
V
L
S
A
L
I
L
A
C
F
R
E
K
P
P
F
F
S
A
199
ABCC4 3
P
V
Y
Q
E
V
K
P
N
P
L
Q
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
ABCC5 59
L
S
L
D
A
S
M
H
S
Q
L
R
I
L
D
E
E
H
P
K
G
K
Y
H
H
G
L
S
A
L
K
P
I
R
T
T
S
K
H
-
-
Q
H
P
V
D
N
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
104
ABCC6 120
F
L
I
H
T
R
K
K
V
Q
-
S
S
G
V
L
F
G
Y
W
L
L
C
F
V
L
P
A
T
N
A
A
Q
-
-
-
A
S
G
A
G
F
Q
S
D
P
V
H
L
S
T
Y
L
C
L
S
L
V
V
A
Q
F
V
L
S
C
L
A
D
Q
P
P
F
F
P
E
195
ABCC7 2
Q
S
L
E
K
A
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
ABCC9 120
V
Y
Y
H
N
I
E
T
S
N
F
P
K
L
L
L
A
L
F
L
Y
W
V
M
A
F
T
K
T
I
K
L
V
K
Y
C
Q
S
G
L
D
I
S
N
L
R
F
C
I
T
G
M
M
V
I
L
N
G
L
L
M
A
V
E
I
N
V
I
R
V
R
R
Y
V
F
F
M
N
P
199
ABCC10 120
W
V
L
A
H
S
P
H
H
S
R
G
P
L
A
L
L
V
A
L
L
P
A
P
A
L
V
L
T
V
L
W
H
C
Q
R
G
T
L
L
P
P
L
L
P
G
P
M
A
R
L
C
L
L
I
L
Q
L
A
A
L
L
A
Y
A
L
G
W
A
A
P
G
G
P
R
E
P
W
199
ABCC11 42
P
W
S
Q
Q
E
R
N
P
E
A
P
G
R
A
A
V
P
P
W
G
K
Y
D
A
A
L
R
T
M
I
P
F
R
P
K
P
R
F
P
A
P
Q
P
L
D
N
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
89
ABCC12 6
P
Y
L
I
S
D
L
D
Q
R
G
R
R
R
S
F
A
-
-
-
E
R
Y
D
P
S
L
K
T
M
I
P
V
R
P
C
A
R
L
-
A
P
N
P
V
D
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
49