Mutations at homologous positions to ABCC7 p.Gly576
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Gly576Ala
p.Gly576*
p.Gly576Arg
|
D
N
-
-
D
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Leu571Ser
p.Leu571Asp
p.Asp572Asn
p.Asp572Met
p.Asp572Ala
p.Ser573Glu
p.Ser573Cys
p.Ser573Ala
p.Pro574His
p.Pro574Ser
p.Pro574Ala
p.Phe575Tyr
p.Phe575Thr
p.Tyr577Phe
p.Tyr577His
p.Tyr577Lys
p.Tyr577Glu
p.Asp579Gly
p.Leu581Phe
|
D
D
D
D
?
D
D
D
D
?
D
D
?
N
N
?
D
D
?
N
N
?
D
D
D
D
D
D
D
?
D
N
?
N
D
?
N
N
N
N
?
D
N
?
D
N
?
D
D
N
N
?
|
| ABCC1 |
p.Asp793Leu
p.Asp793Glu
p.Asp793Asn
p.Asp793Gln
p.Asp793Ser
p.Pro794Ala
p.Pro794Asp
|
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCC2 |
p.Asp786Glu
p.Ser789Phe
p.Ser789Cys
p.Asp792Ala
|
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCC6 |
p.Ala781Val
p.Val787Ile
|
D
D
D
N
N
D
|
| ABCC8 |
p.Asp854Asn
p.Asp854Glu
p.Asp860Ala
|
D
D
?
D
D
?
D
D
?
|
The alignment around the queried position:
1012ABCC7 537
N
V
G
I
S
L
V
V
L
A
N
T
K
M
K
K
I
616
ABCC1 759
T
E
I
G
E
K
G
V
N
S
G
Q
K
Q
R
V
S
L
A
R
A
Y
S
N
A
D
I
Y
L
F
L
S
A
V
D
A
H
V
G
K
H
I
F
E
N
V
I
G
P
K
G
M
L
K
N
K
T
R
I
L
V
T
S
M
S
Y
L
P
V
D
V
I
838
ABCC2 752
A
E
I
G
E
G
I
N
L
S
G
G
Q
K
Q
I
S
L
A
R
A
T
Y
Q
N
L
D
I
Y
L
L
D
P
L
A
V
A
H
V
G
K
H
I
F
K
V
L
G
P
N
L
L
K
G
K
T
R
L
L
V
T
H
S
M
H
F
L
P
Q
V
D
E
I
831
ABCC3 742
E
I
G
E
K
G
I
N
L
S
G
G
Q
R
Q
R
V
S
L
A
R
A
Y
S
D
A
I
F
L
L
D
D
P
L
S
A
V
D
S
H
V
A
K
H
I
F
D
H
V
I
G
P
E
G
L
A
G
K
T
R
V
L
V
H
G
I
S
F
L
P
Q
T
D
F
I
821
ABCC4 526
T
V
I
G
D
G
T
T
L
S
G
Q
K
A
R
V
N
L
A
R
V
Y
Q
D
A
D
I
L
D
D
P
L
S
A
V
D
A
E
V
S
R
H
L
F
L
C
I
C
Q
I
-
-
L
H
E
K
I
I
L
V
T
H
Q
L
Q
Y
L
K
A
S
Q
I
603
ABCC5 676
T
E
I
G
E
R
G
A
N
L
S
G
G
Q
R
Q
R
I
S
L
A
R
A
L
Y
S
D
R
S
I
Y
I
L
D
D
P
L
S
A
L
D
A
H
V
G
N
H
I
F
N
S
A
I
R
K
H
-
-
L
K
S
K
T
V
L
F
V
T
H
Q
L
Q
Y
L
V
D
C
D
E
V
753
ABCC6 744
T
S
I
G
E
G
N
L
S
G
Q
K
Q
L
S
L
A
V
K
A
A
V
Y
L
L
D
P
L
A
L
D
A
H
G
Q
H
V
F
Q
V
I
G
P
G
G
L
L
Q
G
T
T
I
L
H
A
L
H
I
L
P
Q
D
W
I
823
ABCC8 820
T
Q
I
G
E
G
I
N
L
G
G
Q
Q
I
S
V
A
A
L
Y
Q
H
A
N
V
V
F
L
P
F
S
A
L
I
H
L
S
D
H
L
M
Q
A
G
I
L
E
L
L
R
D
D
R
T
V
V
L
V
T
L
Q
Y
L
P
H
A
D
I
899
ABCC9 803
T
E
I
G
E
R
G
I
N
L
S
G
G
Q
R
Q
R
I
C
V
A
R
A
L
Y
Q
N
T
N
I
V
F
L
D
D
P
F
S
A
L
D
I
H
L
S
D
H
L
M
Q
E
G
I
L
K
F
L
Q
D
D
K
R
T
L
V
L
V
T
H
K
L
Q
Y
L
T
H
A
D
W
I
882
ABCC10 717
T
E
V
G
E
K
G
V
T
L
S
G
G
Q
R
A
R
I
A
L
A
R
A
V
Y
Q
E
K
E
L
Y
L
L
D
D
P
L
A
A
V
D
A
D
V
A
N
H
L
L
H
R
C
I
L
G
M
L
S
Y
T
T
R
-
-
L
L
C
T
H
R
T
E
Y
L
E
R
A
D
A
V
794
ABCC11 625
T
E
I
G
E
R
G
L
N
L
S
G
G
Q
K
Q
R
I
S
L
A
R
A
V
Y
S
D
R
Q
I
Y
L
L
D
D
P
L
S
A
V
D
A
H
V
G
K
H
I
F
E
E
C
I
K
K
T
-
-
L
R
G
K
T
V
V
L
V
T
H
Q
L
Q
Y
L
E
F
C
G
Q
I
702
ABCC12 594
T
E
I
G
E
R
G
L
N
L
S
G
G
Q
R
Q
R
I
S
L
A
R
A
V
Y
S
D
R
Q
L
Y
L
L
D
D
P
L
S
A
V
D
A
H
V
G
K
H
V
F
E
E
C
I
K
K
T
-
-
L
R
G
K
T
V
V
L
V
T
H
Q
L
Q
F
L
E
S
C
D
E
V
671