Mutations at homologous positions to ABCC4 p.Phe368
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC4 |
p.Phe368Leu
p.Phe368Trp
p.Phe368Tyr
p.Phe368Ala
|
N
D
?
D
D
?
N
N
?
N
D
?
|
| ABCC7 |
p.Gln353Cys
p.Gln353His
p.Gln353Ala
p.Gln353*
|
D
N
?
D
N
D
N
?
-
-
|
Mutations +/- 5 a.a. around the position:
| ABCC4 |
p.Thr364Arg
|
D
D
?
|
| ABCC1 |
p.Phe594Ala
p.Phe594Trp
p.Phe594Tyr
p.Pro595Ala
p.Asn597Ala
p.Pro600Ala
p.Ser604Ala
p.Ser604Thr
|
D
D
?
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
D
N
?
D
N
?
|
| ABCC6 |
p.Ser587Cys
|
N
N
N
|
| ABCC7 |
p.Met348Lys
p.Met348Cys
p.Met348Val
p.Met348Thr
p.Met348Ala
p.Met348Arg
p.Met348Asn
p.Met348Ile
p.Met348Glu
p.Ala349Val
p.Ala349Cys
p.Ala349Ser
p.Ala349Lys
p.Val350Cys
p.Val350Ala
p.Val350Arg
p.Thr351Ala
p.Thr351Cys
p.Thr351Ser
p.Thr351Arg
p.Arg352Gln
p.Arg352His
p.Arg352Cys
p.Arg352Glu
p.Arg352Trp
p.Arg352Lys
p.Arg352Ala
p.Arg352Gly
p.Phe354Ile
p.Phe354Arg
p.Pro355Ser
p.Pro355Leu
p.Pro355Ala
p.Pro355Phe
p.Trp356Cys
p.Trp356*
p.Ala357Thr
p.Val358Ile
|
D
D
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
D
D
?
N
N
D
D
N
?
N
N
?
D
N
?
D
N
?
D
N
?
D
D
?
D
N
?
D
N
?
D
N
D
N
?
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
N
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
-
-
D
N
?
N
N
?
|
| ABCC8 |
p.Phe591Leu
p.Arg598*
p.Arg598*
|
N
D
?
-
-
?
-
-
?
|
The alignment around the queried position:
ABCC4 331
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
I
V
S
A
I
V
S
I
R
R
I
Q
T
F
L
L
L
D
E
I
S
Q
R
N
R
Q
L
S
D
G
K
K
408
ABCC1 560
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
I
I
V
Q
A
S
V
S
L
K
R
L
R
I
F
L
S
H
E
E
L
E
P
D
S
I
R
P
V
K
D
G
638
ABCC2 557
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
I
S
S
M
L
Q
A
V
S
T
E
R
L
E
K
Y
L
G
G
D
D
L
D
T
S
A
I
R
H
D
C
N
F
D
K
635
ABCC3 546
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
I
S
N
L
T
Q
A
S
V
S
L
K
R
I
Q
Q
F
L
Q
E
E
L
D
P
Q
S
V
E
R
K
T
I
S
P
G
624
ABCC5 413
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
V
K
S
L
S
E
A
S
V
A
V
D
R
F
K
S
L
F
L
M
E
E
V
H
M
I
K
N
K
P
A
S
P
H
I
K
489
ABCC6 546
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
I
H
S
L
V
Q
A
R
V
S
F
D
L
V
T
F
L
C
L
E
E
V
D
P
G
V
D
S
S
S
S
G
S
A
623
ABCC7 317
-
-
-
D
G
A
I
I
D
Q
K
K
T
E
Y
N
L
-
-
-
-
-
389
ABCC8 554
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
V
S
T
K
A
L
V
S
Q
K
L
S
E
F
L
S
S
A
E
I
E
E
Q
C
A
P
H
E
P
-
T
P
631
ABCC9 550
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
V
R
A
V
K
A
I
I
S
V
Q
K
L
N
E
F
L
L
S
D
E
I
G
D
D
S
W
R
T
G
E
S
S
L
P
627
ABCC10 517
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
I
N
G
L
L
E
A
K
V
S
L
D
R
I
Q
L
F
L
D
L
P
N
H
N
P
Q
A
Y
Y
S
-
P
D
P
P
A
592
ABCC11 397
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
V
K
G
L
T
N
S
K
S
A
V
M
R
F
K
K
F
F
L
Q
E
S
P
V
F
Y
V
Q
T
L
Q
D
P
S
K
473
ABCC12 357
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
I
K
A
M
A
E
A
N
V
S
L
R
R
M
K
K
I
L
I
D
K
S
P
P
S
Y
I
T
Q
P
E
D
P
D
T
V
433