Mutations at homologous positions to ABCC7 p.Phe1068
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Phe1068Cys
p.Phe1068Trp
p.Phe1068Met
|
D
D
?
D
N
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Trp1063*
p.Thr1064Cys
p.Leu1065Pro
p.Leu1065Cys
p.Leu1065Arg
p.Arg1066Cys
p.Arg1066Leu
p.Arg1066His
p.Arg1066Ser
p.Arg1066Met
p.Arg1066Gly
p.Ala1067Val
p.Ala1067Thr
p.Ala1067Cys
p.Gly1069Arg
p.Gly1069Cys
p.Arg1070Gln
p.Arg1070Trp
p.Arg1070Pro
p.Arg1070Ala
p.Arg1070Asp
p.Arg1070Lys
p.Gln1071His
p.Gln1071Pro
p.Pro1072Leu
p.Pro1072Thr
p.Pro1072Ala
p.Tyr1073Cys
|
-
-
D
D
?
D
D
D
D
D
?
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
N
D
D
D
?
N
N
N
D
?
D
N
D
D
D
D
D
N
N
?
D
N
?
N
N
?
D
D
?
N
D
D
N
N
?
N
N
?
N
N
?
N
N
?
|
| ABCC1 |
p.Val1164Ile
p.Arg1166Ala
p.Arg1166Lys
p.Arg1173Ala
|
N
N
?
D
D
?
D
D
?
N
D
?
|
| ABCC2 |
p.Ile1173Phe
p.Ile1173Arg
p.Arg1174His
p.Arg1181Leu
|
N
D
D
D
D
D
D
D
?
D
D
N
|
| ABCC6 |
p.Arg1138Gln
p.Arg1138Trp
p.Arg1138Pro
p.Arg1138*
p.Ala1139Thr
p.Arg1141*
p.Arg1141Cys
p.Arg1141Trp
p.Gln1143*
|
D
D
D
D
D
D
D
D
D
-
-
D
D
D
D
-
-
D
N
D
D
D
D
D
-
-
D
|
| ABCC8 |
p.Arg1217Lys
p.Tyr1218His
|
N
N
?
N
N
?
|
The alignment around the queried position:
ABCC7 1029
L
A
F
L
Q
S
Q
Q
L
L
E
S
P
I
L
S
L
E
T
F
H
L
N
L
F
L
S
T
R
I
I
1108
ABCC1 1129
V
Q
F
Y
V
A
S
Q
L
L
S
S
R
S
V
Y
S
H
F
T
L
L
V
S
I
A
F
E
E
Q
E
F
I
H
Q
S
L
V
N
Q
K
A
S
I
V
A
N
L
A
V
L
V
1208
ABCC2 1137
V
Q
M
F
Y
V
S
T
S
R
Q
L
R
L
D
S
V
T
R
S
I
Y
S
H
F
S
E
T
V
S
G
L
P
V
A
F
E
H
Q
Q
F
L
K
H
N
E
R
I
D
T
N
Q
K
C
V
F
S
W
I
T
S
N
R
W
L
A
I
L
E
L
V
G
N
1216
ABCC3 1125
V
Q
R
F
Y
A
A
T
S
R
Q
L
K
L
E
S
V
S
R
S
P
I
Y
S
H
F
S
E
T
V
T
G
A
S
V
I
R
A
Y
N
R
S
R
D
F
E
I
S
D
T
K
V
D
A
N
Q
R
S
C
Y
P
Y
I
I
S
N
R
W
L
S
I
G
V
E
F
V
G
N
1204
ABCC4 878
L
R
R
Y
F
L
E
T
S
R
D
V
K
R
L
E
S
T
T
R
S
P
F
S
H
L
S
S
S
L
Q
G
L
W
T
I
R
A
Y
K
A
E
E
R
C
Q
E
L
F
D
A
H
Q
D
L
H
S
E
A
W
F
L
F
L
T
T
S
R
W
F
A
V
R
L
D
A
I
A
957
ABCC5 1028
L
H
I
V
S
R
V
L
I
R
E
L
K
R
L
D
N
I
T
Q
S
P
F
L
S
H
I
T
S
S
I
Q
G
L
A
T
I
H
A
Y
N
K
G
Q
E
F
L
H
R
Y
Q
E
L
L
D
D
N
Q
A
P
F
F
L
F
T
C
A
M
W
L
A
V
R
L
D
L
I
S
I
1107
ABCC6 1101
F
Q
S
L
Y
V
V
S
S
C
Q
L
R
L
E
S
A
S
Y
S
V
C
S
H
A
E
F
Q
S
T
V
V
F
T
A
P
F
V
A
Q
N
N
A
R
V
D
E
S
Q
R
I
S
F
P
L
V
A
D
R
W
L
A
A
N
V
E
L
L
G
N
1180
ABCC8 1177
I
K
Y
F
V
R
D
L
Q
L
D
T
T
L
L
L
H
F
E
T
V
E
G
T
T
I
R
A
F
E
A
R
F
Q
K
L
E
T
D
S
N
N
I
A
L
F
L
T
A
A
N
R
W
L
E
M
E
Y
G
1256
ABCC9 1149
I
Q
K
Y
F
V
A
S
K
D
L
Q
E
L
D
D
S
T
Q
L
P
L
L
C
H
F
S
E
T
A
E
G
L
T
T
I
R
A
F
R
H
E
T
R
F
K
Q
L
E
L
T
D
T
N
N
I
A
Y
L
F
L
S
A
A
N
R
W
L
E
V
R
T
D
Y
L
G
A
1228
ABCC10 1081
V
Q
R
H
Y
R
A
S
S
R
E
L
R
R
L
G
S
L
T
L
S
P
L
Y
S
H
L
A
D
T
L
A
G
L
S
V
L
R
A
T
G
A
T
Y
R
F
E
E
E
N
L
R
L
L
E
L
N
Q
R
C
Q
F
A
T
S
A
T
M
Q
W
L
D
I
R
L
Q
L
M
G
A
1160
ABCC11 976
Y
Y
M
M
F
K
K
A
I
G
V
F
K
R
L
E
Y
S
R
S
P
L
F
S
H
I
L
N
S
L
Q
G
L
S
S
I
H
V
Y
G
K
T
E
D
F
I
S
Q
F
K
R
L
T
D
A
Q
N
N
Y
L
L
L
F
L
S
S
T
R
W
M
A
L
R
L
E
I
M
T
N
1055
ABCC12 965
L
L
R
I
F
H
R
G
V
Q
E
L
K
K
V
E
N
V
S
R
S
P
W
F
T
H
I
T
S
S
M
Q
G
L
G
I
I
H
A
Y
G
K
K
E
S
C
I
T
-
-
-
-
-
-
-
-
-
-
Y
H
L
L
Y
F
N
C
A
L
R
W
F
A
L
R
M
D
V
L
M
N
1034