Mutations at homologous positions to ABCC7 p.Pro324
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCC7 |
p.Pro324Ala
p.Pro324Gly
|
N
N
?
N
D
?
|
ABCC8 |
p.Gly561Ser
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
ABCC7 |
p.Phe319Val
p.Leu320Phe
p.Leu320Val
p.Ser321Ala
p.Val322Ala
p.Val322Met
p.Leu323Pro
p.Tyr325Cys
p.Ala326Cys
p.Leu327Arg
p.Leu327Cys
p.Ile328Cys
p.Lys329Ala
p.Lys329Cys
p.Lys329Glu
|
N
N
?
N
N
N
N
D
N
N
?
D
N
?
N
N
D
N
?
D
D
?
N
N
?
D
D
?
N
D
?
N
N
?
N
N
?
D
N
?
D
N
?
|
ABCC1 |
p.Cys563Ser
p.Cys563Ala
p.Thr564Ala
p.Phe565Leu
p.Phe565Ser
p.Phe565Ala
p.Tyr568Ala
p.Tyr568Ser
p.Tyr568Trp
p.Tyr568Phe
p.Thr570Ala
p.Asp572Arg
p.Asp572Asn
|
N
N
?
N
N
?
N
D
?
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
D
?
N
N
?
D
D
?
D
D
?
|
ABCC2 |
p.Phe562Leu
|
D
D
?
|
ABCC3 |
p.Leu548Gln
p.Thr550Ala
|
D
D
?
D
D
?
|
ABCC8 |
p.Val560Gly
p.Val560Met
p.Phe565Ser
|
N
N
?
D
N
N
N
D
?
|
The alignment around the queried position:
ABCC7 285
E
L
R
T
L
T
A
N
S
S
-
-
-
361
ABCC1 528
V
L
A
I
Q
E
L
K
V
L
K
S
A
Y
L
S
A
V
G
F
V
F
L
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
I
I
606
ABCC2 525
V
Q
N
L
R
K
K
E
L
K
N
L
L
A
F
S
Q
L
Q
C
V
V
I
F
V
F
Q
L
T
P
V
L
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
I
S
S
M
603
ABCC3 514
V
E
G
I
Q
G
E
L
Q
L
L
R
A
Y
L
H
T
T
T
T
F
T
W
M
C
S
P
F
L
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
I
S
N
L
592
ABCC4 299
I
T
N
L
R
K
E
I
S
K
I
L
R
S
S
C
L
R
G
M
N
L
A
S
F
F
S
A
S
K
I
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
I
V
376
ABCC5 381
V
Q
K
I
R
E
E
E
R
R
I
L
E
K
A
G
Y
F
Q
S
I
T
V
G
V
A
P
I
V
V
V
I
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
V
K
S
L
457
ABCC6 514
L
G
I
G
Q
L
G
A
L
R
T
S
G
L
L
F
S
V
L
V
S
F
Q
V
S
T
F
L
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
I
H
S
L
591
ABCC8 522
V
E
T
T
R
K
E
M
T
R
A
A
I
Y
T
S
I
S
I
F
M
N
T
A
I
I
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
V
S
T
600
ABCC9 518
V
E
E
T
R
M
K
E
L
S
L
K
T
F
A
L
Y
T
S
L
S
I
F
M
N
A
A
I
P
I
A
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
V
R
A
595
ABCC10 485
V
E
A
C
R
A
R
E
L
G
R
L
R
V
I
K
Y
L
D
A
A
C
V
Y
L
W
A
A
L
P
V
V
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
I
N
G
L
561
ABCC11 365
I
E
D
L
R
R
K
E
R
K
L
L
E
K
C
G
L
V
Q
S
L
T
S
I
T
L
F
I
I
P
T
V
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
V
K
G
L
441
ABCC12 325
I
Q
D
I
R
R
R
E
R
K
L
L
E
K
A
G
F
V
Q
S
G
N
S
A
L
A
P
I
V
S
T
I
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
I
K
A
M
401