Mutations at homologous positions to ABCC1 p.Cys1423
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC1 |
p.Cys1423Ala
|
D
D
?
|
| ABCC7 |
p.Leu1339Phe
|
D
N
|
Mutations +/- 5 a.a. around the position:
| ABCC3 |
p.Gly1423Arg
|
D
D
?
|
| ABCC4 |
p.Ser1173Ala
|
N
N
?
|
| ABCC6 |
p.Lys1394Asn
p.Arg1398*
p.Glu1400Lys
|
N
N
D
-
-
D
D
D
D
|
| ABCC7 |
p.Leu1335Pro
p.Leu1335Phe
p.Asp1336Cys
p.Phe1337Val
p.Val1338Thr
p.Asp1341Cys
p.Cys1344Ser
p.Cys1344Ala
p.Cys1344Tyr
|
D
D
D
D
D
D
?
N
N
N
N
?
D
D
?
N
N
?
N
N
?
N
N
?
|
| ABCC8 |
p.Gly1469*
p.Gly1469Val
p.Asp1471Asn
p.Asp1471His
p.Gly1477Arg
p.Gly1478Val
p.Gly1478Arg
|
-
-
?
D
D
?
N
D
D
D
D
D
D
D
?
D
D
?
D
D
?
|
The alignment around the queried position:
1782ABCC1 1384
L
R
M
N
L
D
P
F
S
Q
Y
S
D
E
E
V
W
S
L
E
L
A
H
L
K
D
F
V
S
A
L
P
D
K
L
D
H
E
A
E
G
G
E
N
S
Q
Q
V
L
A
R
A
L
L
R
K
T
K
I
L
V
L
A
T
A
V
D
L
E
1463
ABCC2 1391
L
M
N
L
D
P
F
N
N
Y
S
D
E
E
I
W
K
A
L
E
L
A
L
K
S
F
V
A
S
L
Q
L
G
L
S
H
E
V
T
E
A
G
G
N
L
S
I
G
Q
R
Q
L
L
L
G
R
L
L
R
K
S
K
I
L
V
L
D
E
A
T
A
A
V
D
L
E
1470
ABCC3 1380
L
M
N
L
D
P
F
G
S
Y
S
E
E
D
I
W
W
L
E
L
S
H
L
H
F
V
S
S
Q
P
A
G
L
D
F
Q
C
S
E
G
E
N
L
S
V
G
Q
R
Q
L
V
C
L
A
R
A
L
L
R
K
S
R
I
L
V
L
D
E
A
T
A
A
I
D
L
E
1459
ABCC4 1131
M
R
K
N
L
D
P
F
N
E
H
D
E
E
L
W
N
A
L
Q
E
V
Q
L
K
E
T
I
E
D
L
P
G
K
M
D
T
E
L
A
E
G
S
N
F
S
V
G
Q
R
Q
L
V
C
L
A
R
A
I
L
R
K
N
Q
I
L
I
I
D
A
T
A
N
V
D
P
R
1210
ABCC5 1284
V
R
S
N
L
D
P
F
N
Q
Y
T
E
D
Q
I
W
D
A
L
E
R
T
H
M
K
E
C
I
A
Q
L
P
L
K
L
E
S
E
V
M
E
N
G
D
N
F
S
V
G
E
R
Q
L
L
C
I
A
R
A
L
L
R
H
C
K
I
L
I
L
D
E
A
T
A
A
M
D
T
E
1363
ABCC6 1356
L
M
N
L
L
L
Q
E
H
S
D
A
I
W
A
A
L
E
T
V
Q
L
K
A
L
V
A
S
L
P
G
Q
L
Q
Y
C
A
D
G
D
L
V
K
Q
L
L
C
L
A
R
A
L
K
T
Q
I
L
L
D
A
T
A
A
V
D
P
G
1435
ABCC7 1300
F
R
L
P
E
K
A
D
G
S
Q
F
P
G
K
V
G
G
V
M
L
A
S
V
L
S
K
K
L
L
S
L
P
1379
ABCC8 1435
I
F
N
L
D
P
E
R
K
C
D
T
L
W
E
A
L
I
Q
L
K
L
V
V
K
A
L
P
G
L
A
I
I
T
E
E
N
F
Q
R
Q
L
F
C
L
A
A
F
V
R
K
T
I
F
I
M
A
T
A
S
I
M
A
1514
ABCC9 1403
I
R
F
N
L
D
P
E
C
K
C
T
D
D
R
L
W
E
A
L
E
I
A
Q
L
K
N
M
V
K
S
L
P
G
G
L
D
A
V
V
T
E
G
G
E
N
F
S
V
G
Q
R
Q
L
F
C
L
A
R
F
V
R
K
S
S
I
L
I
M
D
E
A
T
A
S
I
D
M
A
1482
ABCC10 1337
V
R
E
N
L
D
P
Q
G
L
H
K
D
R
A
L
W
Q
A
L
K
Q
C
H
L
S
E
V
I
T
S
M
G
G
-
L
D
G
E
L
G
E
G
G
R
S
L
S
L
Q
R
Q
L
L
C
L
A
R
A
L
L
T
D
A
K
I
L
C
I
D
E
A
T
A
S
V
D
Q
K
1415
ABCC11 1232
I
R
F
N
L
D
P
F
D
R
H
T
D
Q
Q
I
W
D
A
L
E
R
T
F
L
T
K
A
I
S
K
F
P
K
K
L
H
T
D
V
V
E
N
G
G
N
F
S
V
G
E
R
Q
L
L
C
I
A
R
A
V
L
R
N
S
K
I
I
L
I
D
E
A
T
A
S
I
D
M
E
1311
ABCC12 1211
V
R
Y
N
L
D
P
F
E
S
H
T
E
M
L
W
Q
V
L
E
R
T
F
M
R
D
T
I
M
K
L
P
E
K
L
Q
A
E
V
T
E
N
G
E
N
F
S
V
G
E
R
Q
L
L
C
V
A
R
A
L
L
R
N
S
K
I
I
L
L
D
E
A
T
A
S
M
D
S
K
1290