ABCC1 p.Glu298Asp
| Predicted by SNAP2: | A: N (78%), C: N (66%), D: N (82%), F: N (53%), G: N (72%), H: N (87%), I: N (72%), K: N (72%), L: N (72%), M: N (72%), N: N (78%), P: N (57%), Q: N (87%), R: N (72%), S: N (78%), T: N (72%), V: N (72%), W: D (59%), Y: D (53%), |
| Predicted by PROVEAN: | A: D, C: D, D: N, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: N, R: D, S: D, T: D, V: D, W: D, Y: D, |
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[hide] Individual variability in the disposition of and r... Pharmacol Ther. 2011 Mar;129(3):267-89. Epub 2010 Oct 19. Xie HG, Zou JJ, Hu ZY, Zhang JJ, Ye F, Chen SL
Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond.
Pharmacol Ther. 2011 Mar;129(3):267-89. Epub 2010 Oct 19., [PMID:20965214]
Abstract [show]
The widespread use of clopidogrel alone or in combination with aspirin has significantly benefited patients with acute coronary syndrome who are managed medically or by percutaneous coronary intervention and stent implantation, greatly improving their survival. Emerging data have documented that the clopidogrel response may vary from person to person and even from disease to disease, and that genetic and nongenetic factors contribute to that variability. Genetic polymorphisms affecting clopidogrel metabolic bioactivation and platelet function may be responsible, each exerting a small effect. CYP2C19 *2, *3 and *17, CYP2C9 *2 and *3, MDR1*2, and functional variants in the genes encoding platelet membrane receptors and intracellular signaling proteins are involved, and other genetic factors remain to be identified. In addition, nongenetic factors may be influential covariates, such as ethnicity, gender, age, body weight, co-existing diseases, drug-drug interactions, and other factors to be determined. Each piece of the puzzle would be useful to bridge and delineate identified knowledge gaps and to determine future research needs for the risk prediction of fatal complications associated with inadequate clopidogrel therapy in patient care.
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No. Sentence Comment
419 Several SNPs have been identified in the eNOS gene, such as -786T/C in the promoter, 894G/T in exon 7 (causing Glu298Asp), 4a/4b in intron 4, and more.
X
ABCC1 p.Glu298Asp 20965214:419:111
status: NEW