ABCC6 p.Ser245Thr
| Predicted by SNAP2: | A: N (78%), C: N (72%), D: D (75%), E: D (75%), F: D (71%), G: D (53%), H: D (66%), I: D (63%), K: D (71%), L: D (66%), M: D (63%), N: D (59%), P: D (66%), Q: D (63%), R: D (75%), T: N (61%), V: D (59%), W: D (75%), Y: D (71%), |
| Predicted by PROVEAN: | A: N, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, T: D, V: D, W: D, Y: D, |
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[hide] Membrane insertion and topology of the amino-termi... FEBS Lett. 2015 Dec 21;589(24 Pt B):3921-8. doi: 10.1016/j.febslet.2015.10.030. Epub 2015 Nov 3. Cuviello F, Tellgren-Roth A, Lara P, Ruud Selin F, Monne M, Bisaccia F, Nilsson I, Ostuni A
Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6 (MRP6).
FEBS Lett. 2015 Dec 21;589(24 Pt B):3921-8. doi: 10.1016/j.febslet.2015.10.030. Epub 2015 Nov 3., [PMID:26545497]
Abstract [show]
The function of the ATP-binding cassette transporter MRP6 is unknown but mutations in its gene cause pseudoxanthoma elasticum. We have investigated the membrane topology of the N-terminal transmembrane domain TMD0 of MRP6 and the membrane integration and orientation propensities of its transmembrane segments (TMs) by glycosylation mapping. Results demonstrate that TMD0 has five TMs, an Nout-Cin topology and that the less hydrophobic TMs have strong preference for their orientation in the membrane that affects the neighboring TMs. Two disease-causing mutations changing the number of positive charges in the loops of TMD0 did not affect the membrane insertion efficiencies of the adjacent TMs.
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No. Sentence Comment
60 To exclude the possibility that the lack of glycosylation in the C-terminal tail was due to the presence of a serine instead of a threonine in the glycosylation site, one of them was mutated into threonine (S245T TMD0-L0).
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ABCC6 p.Ser245Thr 26545497:60:207
status: NEW