Mutations at homologous positions to ABCB1 p.Ile409
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Ile409Glu
p.Val1052Ile
|
D
D
?
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ile1050Thr
p.Ile1050Cys
p.Pro1051Ala
|
N
D
?
N
D
?
D
D
?
|
| ABCB11 |
p.Arg432Thr
p.Asp440Glu
p.Arg1090*
|
N
D
D
D
N
?
-
-
?
|
| ABCB4 |
p.Arg1046*
|
-
-
?
|
| ABCB5 |
p.Ser584Gly
|
D
D
?
|
The alignment around the queried position:
ABCB1 371
N
K
S
I
D
S
Y
S
S
G
H
K
P
D
N
-
I
K
G
N
L
F
V
H
R
K
E
V
K
L
K
G
L
N
L
K
Q
S
G
Q
T
V
A
L
V
T
T
M
Q
R
D
P
T
449
ABCB1 1014
K
P
L
I
D
S
Y
S
T
E
G
L
M
N
T
-
E
G
N
V
F
G
E
V
V
F
T
R
P
D
L
Q
G
L
S
L
E
V
K
Q
L
A
L
V
V
V
L
L
E
P
L
A
1092
ABCB2 544
R
T
P
R
C
P
P
S
G
-
-
L
L
T
P
L
H
-
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
D
V
L
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
L
L
Q
N
L
Y
Q
P
T
G
G
620
ABCB3 449
R
Q
P
N
L
P
S
P
G
-
-
T
L
A
P
T
T
-
Q
G
V
V
K
F
Q
D
V
S
F
A
Y
P
N
R
P
D
R
P
V
L
K
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
525
ABCB4 373
N
N
P
K
I
D
S
F
S
E
R
G
H
K
P
D
S
-
I
K
N
L
F
N
D
V
H
F
S
P
S
R
A
N
V
K
I
L
K
G
L
N
L
K
V
Q
S
G
Q
A
L
V
G
S
C
G
S
T
T
V
Q
L
I
Q
L
Y
D
P
D
G
451
ABCB4 1013
R
Q
P
L
I
D
S
Y
S
E
E
L
K
P
D
K
-
F
E
G
N
I
T
F
N
E
V
V
F
Y
P
T
A
N
V
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
G
S
G
G
S
T
V
Q
L
E
R
F
Y
D
P
L
A
G
1091
ABCB5 549
K
K
P
N
I
D
S
R
S
Q
E
G
K
P
D
T
-
C
E
G
N
L
E
F
R
E
V
S
F
F
Y
C
R
P
V
F
I
L
R
G
L
S
L
S
I
E
R
G
K
T
V
A
F
V
G
S
S
G
C
G
K
S
T
S
V
Q
L
L
Q
R
L
Y
D
P
V
Q
G
627
ABCB6 570
E
E
T
E
V
K
D
L
P
A
G
P
L
R
F
Q
-
-
K
R
I
E
F
E
N
V
H
F
S
Y
A
D
G
R
E
-
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
645
ABCB7 450
V
D
T
Q
I
K
D
K
V
M
A
S
P
L
Q
I
T
P
Q
T
A
T
V
A
F
D
N
V
H
F
E
Y
I
E
G
Q
K
-
-
V
L
S
G
I
S
F
E
V
P
A
G
K
K
V
A
I
V
G
G
S
G
S
G
K
S
T
I
V
R
L
L
F
R
F
Y
P
Q
K
G
527
ABCB8 451
L
N
P
C
I
P
L
S
G
G
C
C
V
P
K
E
Q
-
L
R
G
S
V
T
F
Q
N
V
C
F
S
Y
P
C
R
P
G
F
E
V
L
K
D
F
T
L
T
L
P
P
G
K
I
V
A
L
V
G
Q
S
G
G
G
K
T
T
V
A
S
L
L
E
R
F
Y
D
P
T
A
G
529
ABCB9 485
R
Q
P
T
M
V
H
D
G
-
-
S
L
A
P
D
H
-
L
E
G
R
V
D
F
E
N
V
T
F
T
Y
R
T
R
P
H
T
Q
V
L
Q
N
V
S
F
S
L
S
P
G
K
V
T
A
L
V
G
P
S
G
S
G
S
S
C
V
N
I
L
E
N
F
Y
P
L
E
G
G
561
ABCB10 471
R
E
P
K
L
P
F
N
E
G
V
I
L
N
E
K
S
-
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
549
ABCB11 399
R
K
P
I
I
D
C
M
S
E
D
Y
K
D
-
I
K
G
E
E
F
N
V
T
F
H
Y
P
S
P
E
V
K
I
L
N
L
N
M
I
K
P
G
E
M
T
A
L
V
P
S
G
G
S
A
L
L
I
Q
F
D
P
C
E
G
477
ABCB11 1057
P
P
I
S
V
Y
N
T
A
G
E
K
W
D
N
-
F
Q
G
K
D
F
V
D
K
F
T
Y
P
S
P
D
S
Q
V
L
N
G
L
S
V
S
I
S
P
G
Q
T
L
F
G
S
C
G
K
T
S
I
Q
L
L
E
F
Y
P
D
Q
G
1135