ABCMdb

ABCB3 p.Arg273His

Predicted by SNAP2:	A: D (80%), C: D (80%), D: D (91%), E: D (85%), F: D (85%), G: D (85%), H: D (80%), I: D (80%), K: D (80%), L: D (85%), M: D (85%), N: D (80%), P: D (85%), Q: D (75%), S: D (75%), T: D (75%), V: D (85%), W: D (85%), Y: D (85%),
Predicted by PROVEAN:	A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, S: D, T: D, V: D, W: D, Y: D,

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Publications
[hide] p53 induces TAP1 and enhances the transport of MHC... Oncogene. 1999 Dec 16;18(54):7740-7. Zhu K, Wang J, Zhu J, Jiang J, Shou J, Chen X
p53 induces TAP1 and enhances the transport of MHC class I peptides.
Oncogene. 1999 Dec 16;18(54):7740-7., [PMID:10618714]

Abstract [show]
The transporter associated with antigen processing (TAP) 1 is required for the major histocompatibility complex (MHC) class I antigen presentation pathway, which plays a key role in host tumor surveillance. Since more than 50% of tumors have a dysfunctional p53, evasion of tumor surveillance by tumor cells may be linked to loss of p53 function. Here we found that TAP1 is strongly induced by p53 and DNA-damaging agents through a p53-responsive element. We also found that p73, which is homologous to p53, is capable of inducing TAP1 and cooperates with p53 to activate TAP1. Furthermore, we found that by inducing TAP1, p53 enhances the transport of MHC class I peptides and expression of surface MHC-peptide complexes, and cooperates with interferon gamma to activate the MHC class I pathway. These results suggest that tumor surveillance may be a mechanism by which p53 and/or p73 function as tumor suppressors.

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Sentences [show]
No. Sentence Comment
89 In contrast, the luciferase activity for TAP1-Fluc was not increased by the mutants p53(V143A), p53(R175H), p53(R249S), or p53(R273H) (Figure 5c), consistent with the observation that mutant p53(R249S) was incapable of inducing TAP1 (Figure 1a). Login to comment
95 5 mg of TAP1-Fluc was co-transfected into H1299 cells with 5 mg of pcDNA3 or a vector that expresses p53(V143A), p53(R175H), p53(R249S), or p53(R273H). Login to comment
190 TAP1-Fluc or GADD45-Fluc was co-transfected into H1299 cells with control vector pcDNA3 or a vector that expresses wild-type p53, p53(V143A), p53(R175H), p53(R249S), p53(R273H), p73a or p73b. Login to comment