Mutations at homologous positions to ABCB1 p.Ser222

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

Mutations +/- 5 a.a. around the position:

The alignment around the queried position:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 521
ABCB1 184
E
G
I
G
D
K
I
G
M
F
F
Q
S
M
A
T
F
F
T
G
F
I
V
G
F
T
R
G
-
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
A
V
W
A
K
I
L
S
S
F
T
D
K
E
L
L
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
 262
ABCB1 827
G
A
I
G
S
R
L
A
V
I
T
Q
N
I
A
N
L
G
T
G
I
I
I
S
F
I
Y
G
-
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
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G
V
V
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M
K
M
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S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
 905
ABCB2 357
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
V
R
G
L
C
L
L
G
I
M
L
W
G
S
-
V
S
L
T
M
V
T
L
I
T
L
P
L
L
F
L
L
P
K
K
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W
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L
L
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Q
V
R
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
M
P
 435
ABCB3 262
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
L
S
I
S
-
P
R
L
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L
L
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L
L
H
M
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D
A
V
A
R
A
G
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V
V
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A
V
G
G
L
Q
 340
ABCB4 186
E
G
I
G
D
K
V
G
M
F
F
Q
A
V
A
T
F
F
A
G
F
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G
-
W
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M
A
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I
L
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L
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A
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A
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K
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L
A
A
Y
A
K
A
G
A
V
A
E
E
A
L
G
A
I
R
 264
ABCB4 826
G
A
T
G
T
R
L
A
L
I
A
Q
N
I
A
N
L
G
T
G
I
I
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F
I
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-
W
Q
L
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L
L
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L
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I
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G
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M
K
L
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A
K
R
D
K
K
E
L
E
A
A
G
K
I
A
T
E
A
I
E
N
I
R
 904
ABCB5 362
G
A
T
G
S
R
I
G
V
L
T
Q
N
A
T
N
M
G
L
S
V
I
I
S
F
I
Y
G
-
W
E
M
T
F
L
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L
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V
L
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M
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T
A
A
M
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A
N
K
D
K
Q
E
L
K
H
A
G
K
I
A
T
E
A
L
E
N
I
R
 440
ABCB6 382
G
L
L
S
Y
L
V
F
N
V
I
P
T
L
A
D
I
I
I
G
I
I
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W
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T
K
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A
M
N
T
Q
E
N
A
T
R
A
R
A
V
D
S
L
L
N
F
E
 461
ABCB7 262
F
V
L
S
A
L
V
F
N
L
L
P
I
M
F
E
V
M
L
V
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M
N
K
A
D
N
D
A
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N
A
A
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D
S
L
L
N
Y
E
 341
ABCB8 264
S
S
F
K
L
V
I
S
Q
G
L
R
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C
T
Q
V
A
G
C
L
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A
R
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M
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A
D
E
A
L
G
N
V
R
 342
ABCB9 298
D
L
V
S
Q
N
I
N
V
F
L
R
N
T
V
K
V
T
G
V
V
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W
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N
I
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L
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Q
N
A
L
A
R
A
S
N
T
A
E
E
T
I
S
A
M
K
 376
ABCB10 284
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
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-
P
N
L
A
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Q
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S
L
A
Q
A
T
Q
L
A
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E
R
I
G
N
V
R
 362
ABCB11 211
D
A
I
A
D
Q
M
A
L
F
I
Q
R
M
T
S
T
I
C
G
F
L
L
G
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F
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G
-
W
K
L
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L
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A
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Y
E
L
K
A
Y
A
K
A
G
V
V
A
D
E
V
I
S
S
M
R
 289
ABCB11 870
G
A
A
G
S
Q
I
G
M
I
V
N
S
F
T
N
V
T
V
A
M
I
I
A
F
S
F
S
-
W
K
L
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L
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F
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L
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A
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M
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T
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F
A
S
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D
K
Q
A
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E
M
V
G
Q
I
T
N
E
A
L
S
N
I
R
 948