Mutations at homologous positions to ABCB1 p.Ser298
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Ser298Cys
p.Ser298Ala
p.Ser298Arg
p.Thr941Ala
p.Thr941Cys
p.Thr941Gly
|
N
D
?
N
N
?
D
D
?
N
N
?
N
N
?
N
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ile293Cys
p.Thr294Cys
p.Thr294Ala
p.Ala295Cys
p.Asn296Cys
p.Asn296Ala
p.Ile297Cys
p.Ile297Arg
p.Ile299Met
p.Ile299Cys
p.Gly300Val
p.Ala301Thr
p.Ala301Val
p.Ala301Cys
p.Ala301Asp
p.Ala302Cys
p.Ala302Arg
p.Phe303Cys
p.Phe303Arg
p.His936Cys
p.Ile937Ser
p.Ile937Cys
p.Phe938Ala
p.Phe938Cys
p.Gly939Val
p.Gly939Cys
p.Ile940Ser
p.Ile940Cys
p.Phe942Ala
p.Phe942Cys
p.Phe942Arg
p.Ser943Ala
p.Ser943Cys
p.Phe944Ala
p.Phe944Cys
p.Thr945Ala
p.Thr945Cys
p.Thr945Arg
p.Thr945Glu
p.Gln946Ala
p.Gln946Cys
p.Gln946Arg
|
N
D
?
D
D
?
N
N
?
N
D
?
D
D
?
D
D
?
N
D
?
D
D
?
N
N
?
N
N
?
D
D
?
N
N
?
N
N
?
N
N
?
D
N
?
N
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
D
?
N
D
?
D
D
?
D
D
?
D
D
?
N
D
?
N
D
?
D
D
?
D
D
?
D
D
?
N
N
?
N
D
?
D
D
?
N
D
?
N
N
?
D
N
?
D
N
?
D
N
?
D
D
?
D
D
?
D
D
?
|
| ABCB11 |
p.Gly327Glu
p.Trp330*
p.Trp330Arg
p.Asn979Asp
p.Gly982Arg
|
D
D
?
-
-
?
D
D
?
N
N
?
D
D
?
|
| ABCB3 |
p.Arg373Cys
p.Ala374Asp
p.Ala374Thr
p.Val379Ile
p.Val379Ala
p.Arg380Gln
|
D
D
?
D
D
?
D
D
?
N
N
N
N
N
?
D
N
?
|
| ABCB4 |
p.Ile299Met
p.Ile299Cys
p.Met301Thr
p.Gly302Ala
p.Ile936Ala
p.Phe941Ser
p.Gln945*
|
N
N
?
N
D
?
N
D
?
D
D
?
N
D
?
D
D
?
-
-
?
|
The alignment around the queried position:
ABCB1 259
Q
L
N
K
L
E
E
A
R
I
I
K
K
A
L
A
S
A
L
Y
G
L
V
S
-
Y
I
G
V
337
ABCB1 902
E
N
T
V
L
T
Q
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
L
R
K
R
F
G
A
Y
L
V
A
H
-
K
L
M
S
F
E
D
V
V
980
ABCB2 432
S
A
M
P
T
V
R
S
F
A
N
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
Q
E
V
A
Y
A
V
N
S
W
T
T
S
I
S
G
M
L
L
K
V
G
I
L
Y
I
G
G
Q
L
V
T
S
-
G
A
V
S
S
G
N
L
V
T
F
V
L
Y
510
ABCB3 337
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
W
R
R
D
L
E
L
Y
L
L
R
V
L
H
L
G
V
Q
M
L
M
L
S
G
L
Q
Q
M
Q
D
-
G
E
L
T
Q
G
S
L
S
F
M
I
Y
415
ABCB4 261
G
A
I
R
T
V
I
A
F
G
G
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
I
K
K
A
I
S
A
N
S
I
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
T
L
V
I
S
-
K
E
T
I
G
N
A
M
T
V
F
F
S
339
ABCB4 901
E
N
I
R
T
V
V
L
T
Q
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Q
K
H
Y
G
I
T
S
I
S
F
S
Y
C
F
F
G
A
Y
L
I
V
N
-
G
H
M
R
F
R
D
V
I
V
F
A
979
ABCB5 437
E
N
I
R
T
I
V
S
L
T
R
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
S
C
Y
A
F
S
H
A
F
I
Y
F
A
Y
A
A
G
F
R
F
G
A
Y
L
I
Q
A
-
G
R
M
T
P
E
G
M
F
I
V
F
T
A
515
ABCB6 458
L
N
F
E
T
V
K
Y
Y
N
A
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
W
K
S
S
A
S
L
V
L
L
N
Q
T
Q
N
L
V
I
G
L
G
L
L
A
G
S
L
L
C
A
Y
F
V
T
E
-
Q
K
L
Q
V
G
D
Y
V
L
F
G
T
Y
536
ABCB7 338
L
N
Y
E
T
V
K
Y
F
N
N
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
L
K
S
T
S
T
L
A
M
L
N
F
G
Q
S
A
I
F
S
V
G
L
T
A
I
M
V
L
A
S
Q
G
V
A
-
G
T
L
T
V
G
D
L
M
V
N
G
L
416
ABCB8 339
G
N
V
R
T
V
R
A
F
A
M
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
E
E
L
G
R
G
I
A
L
F
Q
G
L
S
N
I
A
F
N
C
M
V
L
G
T
L
F
I
G
G
S
L
V
A
G
-
Q
Q
L
T
G
G
D
L
M
S
F
L
V
A
417
ABCB9 373
S
A
M
K
T
V
R
S
F
A
N
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
R
K
E
A
A
A
Y
M
Y
Y
V
W
G
S
G
L
T
L
L
V
V
Q
V
S
I
L
Y
Y
G
G
H
L
V
I
S
-
G
Q
M
T
S
G
N
L
I
A
F
I
I
Y
451
ABCB10 359
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
-
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
437
ABCB11 286
S
S
M
R
T
A
A
F
G
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
I
R
K
G
I
V
M
G
F
F
T
F
V
C
L
I
F
L
A
A
F
Y
G
S
T
L
V
L
D
E
G
E
T
P
G
T
L
V
Q
I
F
L
S
365
ABCB11 945
S
N
I
T
V
A
G
I
G
K
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
I
Q
K
A
I
Y
F
C
F
A
F
A
Q
C
I
M
F
I
A
N
S
A
S
Y
R
Y
Y
I
S
-
E
G
L
H
F
S
Y
V
F
R
V
I
S
A
1023