Mutations at homologous positions to ABCB1 p.Phe601
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Phe601Asn
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ala599Thr
p.Asp602Asn
p.Gly1249Ala
p.Gly1249Cys
p.Val1251Ile
|
N
D
?
N
N
?
D
D
?
D
D
?
N
N
?
|
| ABCB11 |
p.Ile627Thr
p.Gly1292Val
|
N
N
?
D
D
?
|
| ABCB4 |
p.Val599Ile
p.Gly602Ala
p.Glu604Gln
|
N
N
?
N
D
?
N
N
?
|
The alignment around the queried position:
ABCB1 564
E
A
V
Q
V
A
L
D
K
-
-
R
G
T
I
V
I
A
H
L
S
V
N
D
V
I
G
D
G
V
I
V
E
K
G
N
H
E
L
M
K
E
-
K
G
I
Y
F
K
L
V
M
Q
T
G
N
E
V
E
L
N
A
640
ABCB1 1209
E
S
K
V
E
A
L
D
K
-
-
A
R
G
R
I
V
I
A
H
R
L
S
I
Q
N
A
D
L
I
V
V
F
Q
N
R
K
E
H
G
H
Q
Q
A
Q
-
I
Y
S
M
V
S
V
Q
A
G
T
K
R
-
-
-
-
-
1281
ABCB2 736
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
E
R
Y
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
L
M
E
K
-
K
G
C
Y
W
A
M
V
Q
A
P
A
D
A
P
E
-
-
-
-
-
-
809
ABCB3 640
-
-
-
-
Q
E
Q
A
L
Q
D
W
N
S
G
D
R
L
V
I
A
L
Q
V
Q
R
A
H
Q
I
L
V
L
Q
-
-
-
-
-
-
E
G
K
L
Q
K
L
A
Q
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687
ABCB4 566
E
S
E
A
E
V
Q
A
A
L
D
K
-
-
A
R
E
T
T
V
I
H
S
V
N
A
D
I
A
F
D
G
V
I
V
E
Q
G
S
H
S
L
M
K
K
-
E
V
Y
F
L
V
N
Q
T
S
S
I
Q
S
E
-
-
641
ABCB4 1215
E
S
E
K
V
V
Q
E
A
L
D
K
-
-
A
R
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
F
Q
N
G
R
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
-
K
G
I
Y
F
S
M
V
S
V
A
G
T
Q
N
L
-
-
-
-
-
1287
ABCB5 744
D
S
E
K
V
V
Q
H
A
L
D
K
-
-
A
R
T
G
R
T
C
L
V
V
T
H
R
L
S
A
I
Q
N
A
D
L
I
V
V
L
H
N
G
K
I
K
E
Q
G
T
H
Q
E
L
L
R
N
-
R
D
I
Y
F
K
L
V
N
A
Q
S
V
Q
-
-
-
-
-
-
-
-
813
ABCB6 760
S
N
E
R
A
I
Q
A
S
L
A
K
-
-
V
C
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
S
R
-
G
G
V
Y
A
D
M
W
Q
L
Q
-
-
-
-
Q
G
Q
E
E
T
S
832
ABCB7 642
I
T
E
E
T
I
L
G
A
M
K
D
-
-
V
V
K
H
R
T
S
I
F
I
A
H
R
L
S
T
V
V
D
A
D
E
I
I
V
L
D
Q
G
K
V
A
E
R
G
T
H
H
G
L
L
A
N
P
H
S
I
Y
S
E
M
W
H
T
Q
S
S
R
V
Q
N
H
D
N
P
K
719
ABCB8 645
E
S
E
R
V
V
Q
E
A
L
D
R
-
-
A
S
A
G
R
T
V
L
V
I
A
H
R
L
S
T
V
R
G
A
H
C
I
V
V
M
A
D
G
R
V
W
E
A
G
T
H
E
E
L
L
K
K
-
G
G
L
Y
A
E
L
I
R
R
Q
A
L
D
A
P
R
T
A
A
P
P
721
ABCB9 676
E
S
E
Y
L
I
Q
Q
A
I
H
G
-
-
N
L
Q
K
H
T
V
L
I
I
A
R
L
S
T
V
E
H
A
H
L
I
V
V
L
D
K
G
R
V
V
Q
Q
G
T
H
Q
Q
L
L
A
Q
-
G
G
L
Y
A
L
V
Q
R
Q
M
L
G
L
Q
P
A
A
D
F
T
752
ABCB10 667
E
N
E
Y
L
V
Q
E
A
L
D
R
-
-
L
M
D
G
R
T
V
L
V
I
A
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
I
Y
R
K
L
M
N
K
Q
S
F
I
S
A
-
-
-
-
-
-
739
ABCB11 592
E
A
M
Q
E
V
L
S
K
-
-
I
Q
H
G
H
T
I
I
S
V
A
H
L
S
V
R
A
A
D
T
I
G
F
E
H
G
T
A
V
R
G
T
H
E
E
L
L
E
R
-
K
V
Y
F
T
L
V
L
Q
S
Q
G
N
Q
A
L
N
E
E
D
668
ABCB11 1252
E
S
E
K
T
V
Q
V
A
L
D
K
-
-
A
R
E
G
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
D
I
I
A
V
M
A
Q
V
V
I
E
K
T
H
E
L
M
A
Q
-
K
G
A
Y
K
L
V
T
T
G
S
P
I
S
-
-
-
-
-
-
-
1322