Mutations at homologous positions to ABCB1 p.Arg210
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCB1 |
p.Arg210Gly
p.Arg210Ala
p.Tyr853Cys
|
N
D
?
N
D
?
N
D
?
|
Mutations +/- 5 a.a. around the position:
ABCB1 |
p.Ile205Cys
p.Gly207Cys
p.Phe208Cys
p.Thr209Cys
p.Gly211Ala
p.Gly211Cys
p.Trp212Arg
p.Trp212*
p.Ile849Met
p.Ser850Cys
p.Gly854Val
p.Gly854Cys
p.Trp855Arg
p.Trp855Cys
|
N
D
?
D
D
?
N
D
?
N
N
?
N
D
?
N
D
?
D
D
?
-
-
?
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
ABCB10 |
p.Ser305Cys
|
N
D
?
|
ABCB11 |
p.Leu233Ser
p.Gly238Val
p.Thr242Ile
p.Ser901Arg
|
N
D
?
D
D
?
D
D
?
D
D
?
|
ABCB2 |
p.Ile379Val
p.Ile379Ala
|
N
N
?
N
N
?
|
ABCB3 |
p.Met285Cys
p.Thr293Pro
|
N
D
?
D
D
?
|
ABCB4 |
p.Thr217Cys
|
D
D
?
|
The alignment around the queried position:
ABCB1 171
N
T
R
S
K
I
E
V
-
K
L
T
L
V
I
L
I
V
L
V
S
F
T
D
K
L
L
A
Y
A
K
249
ABCB1 814
T
T
R
A
A
Q
V
K
G
N
L
G
T
G
I
I
F
I
-
Q
L
T
L
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
892
ABCB2 344
I
M
S
R
V
T
E
D
T
T
L
S
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
V
R
G
L
C
L
L
G
M
L
W
G
S
-
V
S
L
T
M
V
T
L
T
L
P
L
L
F
L
L
P
K
K
G
K
W
Q
L
L
E
V
Q
V
R
E
S
L
A
K
422
ABCB3 249
L
N
R
L
S
S
D
T
L
M
S
N
W
L
N
A
N
V
L
S
L
V
K
V
V
G
L
Y
G
F
L
S
I
S
-
P
R
L
L
L
S
L
L
H
M
P
F
T
I
A
A
E
K
V
Y
N
T
H
Q
E
V
L
R
E
I
Q
D
A
V
A
R
327
ABCB4 173
L
N
R
L
T
D
D
I
S
K
I
S
E
I
G
D
K
V
G
M
F
F
Q
A
V
A
F
F
A
G
F
I
V
G
F
I
R
G
-
W
K
L
L
V
I
M
A
I
P
I
L
G
L
S
A
A
V
W
A
K
I
L
S
A
F
S
K
E
L
A
A
Y
K
251
ABCB4 813
L
S
T
R
L
A
T
D
A
A
Q
V
Q
G
A
T
G
T
R
L
A
L
I
A
Q
N
I
N
L
G
T
G
I
I
I
S
F
I
Y
G
-
W
Q
L
T
L
L
L
A
V
V
P
I
I
A
V
S
G
I
V
E
M
K
L
L
A
G
N
A
K
R
D
K
K
L
E
A
891
ABCB5 349
L
T
T
I
L
A
I
D
I
A
Q
I
Q
G
A
T
G
S
R
I
G
V
L
T
Q
N
T
N
M
G
L
S
V
I
I
S
F
I
Y
G
-
W
E
M
T
F
L
I
L
S
I
A
P
V
L
A
V
T
G
M
I
E
T
A
A
M
T
G
F
A
N
K
D
K
Q
E
L
K
H
427
ABCB6 369
V
L
R
I
A
D
G
T
S
S
V
T
G
L
L
S
Y
L
V
F
N
V
I
P
T
L
A
D
I
I
I
G
I
I
Y
F
S
M
F
F
N
A
W
F
G
L
I
V
F
L
C
M
S
L
L
T
L
T
I
V
V
T
E
W
R
T
K
F
R
R
A
M
N
T
Q
E
N
A
448
ABCB7 249
L
S
K
A
I
D
R
G
T
R
G
I
S
F
V
L
S
A
L
V
F
N
L
L
P
I
M
F
E
V
M
L
V
S
G
V
L
Y
Y
K
C
G
A
Q
F
L
V
T
L
G
T
L
G
T
Y
T
A
F
T
V
A
V
T
R
W
R
T
R
F
R
I
E
M
N
K
A
D
N
D
328
ABCB8 251
L
V
S
R
L
T
T
D
V
Q
E
F
K
S
S
F
K
L
V
I
S
Q
G
L
R
S
C
T
Q
V
A
G
C
L
V
S
L
S
M
L
S
-
T
R
L
T
L
L
L
M
V
A
T
P
A
L
M
G
V
G
T
L
M
G
S
G
L
R
K
L
S
R
Q
C
Q
E
Q
I
A
R
329
ABCB9 285
L
I
S
R
L
T
S
D
T
T
M
V
S
D
L
V
S
Q
N
I
N
V
F
L
R
N
T
V
K
V
T
G
V
V
V
F
M
F
S
L
S
-
W
Q
L
S
L
V
T
F
M
G
F
P
I
I
M
M
V
S
N
I
Y
G
K
Y
Y
K
R
L
S
K
E
V
Q
N
A
L
A
R
363
ABCB10 271
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
M
M
F
F
V
S
-
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
T
K
V
T
Q
D
S
L
A
Q
349
ABCB11 198
N
T
R
F
S
D
D
N
K
I
N
D
I
A
D
Q
A
L
F
I
Q
M
T
T
I
C
G
F
L
G
F
F
R
-
W
K
L
L
V
I
I
S
V
S
P
L
I
G
I
G
A
T
I
L
S
V
S
K
F
T
D
Y
E
L
K
A
Y
A
K
276
ABCB11 857
L
T
R
L
A
T
D
S
Q
V
G
A
A
G
Q
I
M
I
V
N
S
F
T
N
V
T
V
A
M
I
I
A
F
S
F
S
-
W
K
L
L
V
I
L
C
F
F
P
F
L
A
L
S
G
A
T
Q
T
R
M
L
G
F
S
D
A
L
E
M
935