Mutations at homologous positions to ABCB1 p.Trp232
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Trp232Cys
p.Trp232Arg
p.Trp232Ala
p.Trp232*
p.Glu875Cys
p.Glu875Ala
p.Glu875Arg
|
N
D
?
D
D
?
D
D
?
-
-
?
D
D
?
D
D
?
D
D
?
|
| ABCB2 |
p.Val405Leu
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Leu227Cys
p.Ser228Thr
p.Ser228Cys
p.Ser228Asn
p.Ala229Cys
p.Ala229Val
p.Ala230Cys
p.Ala233Cys
p.Lys234Cys
p.Ile235Cys
p.Ile235Leu
p.Leu236Cys
p.Ser237Cys
p.Ile870Cys
p.Ala871Cys
p.Ala871Phe
p.Gly872Cys
p.Gly872Arg
p.Val873Cys
p.Val874Cys
p.Met876Cys
p.Lys877Cys
p.Met878Cys
p.Leu879Cys
|
N
D
?
N
N
?
N
D
?
D
N
?
D
D
?
N
D
?
D
D
?
N
D
?
D
D
?
N
D
?
N
N
?
D
D
?
D
D
?
N
D
?
N
D
?
D
D
?
D
D
?
D
D
?
N
D
?
N
D
?
D
D
?
D
D
?
N
D
?
D
D
?
|
| ABCB11 |
p.Ala257Gly
p.Ala257Val
p.Gly260Asp
p.Thr923Pro
|
N
N
?
D
D
?
D
N
?
D
D
?
|
| ABCB2 |
p.Tyr409Cys
|
D
D
?
|
| ABCB3 |
p.Arg313His
|
N
N
?
|
The alignment around the queried position:
ABCB1 194
V
-
K
L
T
L
V
I
L
I
V
L
V
S
F
T
D
K
L
L
A
Y
A
K
A
A
V
Q
272
ABCB1 837
N
L
G
T
G
I
I
F
I
-
Q
L
T
L
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
K
I
A
T
E
A
I
E
N
T
V
L
T
Q
E
Q
K
915
ABCB2 367
L
W
Y
L
V
R
G
L
C
L
L
G
M
L
W
G
S
-
V
S
L
T
M
V
T
L
T
L
P
L
L
F
L
L
P
K
K
G
K
W
Q
L
L
E
V
Q
V
R
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
M
P
T
V
R
S
F
A
N
E
E
G
445
ABCB3 272
S
L
V
K
V
V
G
L
Y
G
F
L
S
I
S
-
P
R
L
L
L
S
L
L
H
M
P
F
T
I
A
A
E
K
V
Y
N
T
H
Q
E
V
L
R
E
I
Q
D
A
V
A
R
A
G
Q
V
R
E
A
V
G
L
Q
T
V
R
S
F
G
A
E
E
H
350
ABCB4 196
F
Q
A
V
A
F
F
A
G
F
I
V
G
F
I
R
G
-
W
K
L
L
V
I
M
A
I
P
I
L
G
L
S
A
A
V
W
A
K
I
L
S
A
F
S
K
E
L
A
A
Y
K
A
G
V
A
E
E
A
L
G
A
I
R
T
V
I
A
F
G
G
Q
N
K
274
ABCB4 836
A
Q
N
I
N
L
G
T
G
I
I
I
S
F
I
Y
G
-
W
Q
L
T
L
L
L
A
V
V
P
I
I
A
V
S
G
I
V
E
M
K
L
L
A
G
N
A
K
R
D
K
K
L
E
A
A
G
K
I
A
T
E
A
I
E
N
I
R
T
V
V
L
T
Q
E
R
K
914
ABCB5 372
T
Q
N
T
N
M
G
L
S
V
I
I
S
F
I
Y
G
-
W
E
M
T
F
L
I
L
S
I
A
P
V
L
A
V
T
G
M
I
E
T
A
A
M
T
G
F
A
N
K
D
K
Q
E
L
K
H
A
G
K
I
A
T
E
A
L
E
N
I
R
T
I
V
S
L
T
R
E
K
A
450
ABCB6 392
I
P
T
L
A
D
I
I
I
G
I
I
Y
F
S
M
F
F
N
A
W
F
G
L
I
V
F
L
C
M
S
L
L
T
L
T
I
V
V
T
E
W
R
T
K
F
R
R
A
M
N
T
Q
E
N
A
T
R
A
R
V
D
S
L
L
N
F
E
T
V
K
Y
Y
N
A
E
S
Y
471
ABCB7 272
L
P
I
M
F
E
V
M
L
V
S
G
V
L
Y
Y
K
C
G
A
Q
F
L
V
T
L
G
T
L
G
T
Y
T
A
F
T
V
A
V
T
R
W
R
T
R
F
R
I
E
M
N
K
A
D
N
D
A
G
N
A
A
I
D
S
L
L
N
Y
E
T
V
K
Y
F
N
N
E
R
Y
351
ABCB8 274
L
R
S
C
T
Q
V
A
G
C
L
V
S
L
S
M
L
S
-
T
R
L
T
L
L
L
M
V
A
T
P
A
L
M
G
V
G
T
L
M
G
S
G
L
R
K
L
S
R
Q
C
Q
E
Q
I
A
R
A
M
G
V
A
D
E
A
L
G
N
V
R
T
V
R
A
F
A
M
E
Q
R
352
ABCB9 308
L
R
N
T
V
K
V
T
G
V
V
V
F
M
F
S
L
S
-
W
Q
L
S
L
V
T
F
M
G
F
P
I
I
M
M
V
S
N
I
Y
G
K
Y
Y
K
R
L
S
K
E
V
Q
N
A
L
A
R
A
S
N
T
A
E
E
T
I
S
A
M
K
T
V
R
S
F
A
N
E
E
E
386
ABCB10 294
L
R
A
G
A
Q
A
S
V
G
I
M
M
F
F
V
S
-
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
372
ABCB11 221
I
Q
M
T
T
I
C
G
F
L
G
F
F
R
-
W
K
L
L
V
I
I
S
V
S
P
L
I
G
I
G
A
T
I
L
S
V
S
K
F
T
D
Y
E
L
K
A
Y
A
K
G
V
V
A
D
I
S
S
M
R
T
A
A
F
G
K
299
ABCB11 880
V
N
S
F
T
N
V
T
V
A
M
I
I
A
F
S
F
S
-
W
K
L
L
V
I
L
C
F
F
P
F
L
A
L
S
G
A
T
Q
T
R
M
L
G
F
S
D
A
L
E
M
V
G
Q
T
N
E
A
L
S
N
I
T
V
A
G
I
G
K
E
R
958