Mutations at homologous positions to ABCB1 p.Ala220

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

Mutations +/- 5 a.a. around the position:

The alignment around the queried position:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 519
ABCB1 182
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
S
M
A
T
F
F
T
G
F
I
V
G
F
T
R
G
-
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
A
V
W
A
K
I
L
S
S
F
T
D
K
E
L
L
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
 260
ABCB1 825
V
K
G
A
I
G
S
R
L
A
V
I
T
Q
N
I
A
N
L
G
T
G
I
I
I
S
F
I
Y
G
-
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
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I
A
G
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V
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M
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M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
 903
ABCB2 355
L
S
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
V
R
G
L
C
L
L
G
I
M
L
W
G
S
-
V
S
L
T
M
V
T
L
I
T
L
P
L
L
F
L
L
P
K
K
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W
Y
Q
L
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V
Q
V
R
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
 433
ABCB3 260
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
L
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S
-
P
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L
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L
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L
L
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I
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D
A
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A
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G
Q
V
V
R
E
A
V
G
G
 338
ABCB4 184
I
S
E
G
I
G
D
K
V
G
M
F
F
Q
A
V
A
T
F
F
A
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-
W
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L
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L
A
A
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A
K
A
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A
V
A
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E
A
L
G
A
 262
ABCB4 824
V
Q
G
A
T
G
T
R
L
A
L
I
A
Q
N
I
A
N
L
G
T
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I
I
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F
I
Y
G
-
W
Q
L
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L
L
L
L
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V
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I
A
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M
K
L
L
A
G
N
A
K
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D
K
K
E
L
E
A
A
G
K
I
A
T
E
A
I
E
N
 902
ABCB5 360
I
Q
G
A
T
G
S
R
I
G
V
L
T
Q
N
A
T
N
M
G
L
S
V
I
I
S
F
I
Y
G
-
W
E
M
T
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L
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L
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M
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M
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A
N
K
D
K
Q
E
L
K
H
A
G
K
I
A
T
E
A
L
E
N
 438
ABCB6 380
V
T
G
L
L
S
Y
L
V
F
N
V
I
P
T
L
A
D
I
I
I
G
I
I
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F
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M
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F
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L
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W
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T
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R
A
M
N
T
Q
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N
A
T
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A
R
A
V
D
S
L
L
N
 459
ABCB7 260
I
S
F
V
L
S
A
L
V
F
N
L
L
P
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M
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V
M
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N
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A
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N
D
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N
A
A
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S
L
L
N
 339
ABCB8 262
F
K
S
S
F
K
L
V
I
S
Q
G
L
R
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C
T
Q
V
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G
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C
Q
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I
A
R
A
M
G
V
A
D
E
A
L
G
N
 340
ABCB9 296
V
S
D
L
V
S
Q
N
I
N
V
F
L
R
N
T
V
K
V
T
G
V
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V
F
M
F
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L
S
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W
Q
L
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M
V
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I
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K
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L
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V
Q
N
A
L
A
R
A
S
N
T
A
E
E
T
I
S
A
 374
ABCB10 282
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
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-
P
N
L
A
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L
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P
V
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I
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R
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L
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L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
 360
ABCB11 209
I
N
D
A
I
A
D
Q
M
A
L
F
I
Q
R
M
T
S
T
I
C
G
F
L
L
G
F
F
R
G
-
W
K
L
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L
V
I
I
S
V
S
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L
I
G
I
G
A
A
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G
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F
T
D
Y
E
L
K
A
Y
A
K
A
G
V
V
A
D
E
V
I
S
S
 287
ABCB11 868
V
Q
G
A
A
G
S
Q
I
G
M
I
V
N
S
F
T
N
V
T
V
A
M
I
I
A
F
S
F
S
-
W
K
L
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L
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I
L
C
F
F
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F
L
A
L
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G
A
T
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T
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M
L
T
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F
A
S
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D
K
Q
A
L
E
M
V
G
Q
I
T
N
E
A
L
S
N
 946