Mutations at homologous positions to ABCC7 p.Ala1081
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Ala1081Pro
|
N
N
|
| ABCC1 |
p.Lys1181Ala
|
N
D
?
|
| ABCC8 |
p.Tyr1229Leu
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Leu1077Pro
p.Lys1080Arg
p.Lys1080Ile
p.Lys1080Gln
p.His1085Arg
p.His1085Cys
p.Thr1086Ile
p.Thr1086Ala
|
D
N
D
N
N
?
N
N
?
N
N
?
N
N
D
D
D
?
N
N
N
N
?
|
| ABCC1 |
p.Asp1179Ala
p.Asp1183Ala
p.Asp1183Glu
p.Glu1184Lys
p.Glu1184Ala
|
N
D
?
D
D
?
D
D
?
N
N
?
N
N
?
|
| ABCC2 |
p.Val1188Glu
p.Val1188Gln
|
N
N
?
N
N
?
|
| ABCC3 |
p.Ile1173Phe
|
N
N
?
|
| ABCC8 |
p.Leu1226Met
|
N
N
?
|
| ABCC9 |
p.Arg1197Cys
p.Met1198Ile
|
N
D
?
N
N
|
The alignment around the queried position:
ABCC7 1042
L
E
S
P
I
L
S
L
E
T
F
H
L
N
L
F
L
S
T
R
I
I
1121
ABCC1 1142
L
S
S
R
S
V
Y
S
H
F
T
L
L
V
S
I
A
F
E
E
Q
E
F
I
H
Q
S
L
V
N
Q
K
A
S
I
V
A
N
L
A
V
L
V
I
V
L
A
A
L
F
A
V
I
S
1221
ABCC2 1150
L
D
S
V
T
R
S
I
Y
S
H
F
S
E
T
V
S
G
L
P
V
A
F
E
H
Q
Q
F
L
K
H
N
E
R
I
D
T
N
Q
K
C
V
F
S
W
I
T
S
N
R
W
L
A
I
L
E
L
V
G
N
L
T
V
F
F
S
A
L
M
M
V
I
Y
1229
ABCC3 1138
L
E
S
V
S
R
S
P
I
Y
S
H
F
S
E
T
V
T
G
A
S
V
I
R
A
Y
N
R
S
R
D
F
E
I
S
D
T
K
V
D
A
N
Q
R
S
C
Y
P
Y
I
I
S
N
R
W
L
S
I
G
V
E
F
V
G
N
C
V
V
L
F
A
A
L
F
A
V
I
G
1217
ABCC4 891
R
L
E
S
T
T
R
S
P
F
S
H
L
S
S
S
L
Q
G
L
W
T
I
R
A
Y
K
A
E
E
R
C
Q
E
L
F
D
A
H
Q
D
L
H
S
E
A
W
F
L
F
L
T
T
S
R
W
F
A
V
R
L
D
A
I
A
M
F
V
I
I
V
A
F
G
S
L
I
L
970
ABCC5 1041
R
L
D
N
I
T
Q
S
P
F
L
S
H
I
T
S
S
I
Q
G
L
A
T
I
H
A
Y
N
K
G
Q
E
F
L
H
R
Y
Q
E
L
L
D
D
N
Q
A
P
F
F
L
F
T
C
A
M
W
L
A
V
R
L
D
L
I
S
I
A
L
I
T
T
T
G
L
M
I
V
L
M
1120
ABCC6 1114
L
E
S
A
S
Y
S
V
C
S
H
A
E
F
Q
S
T
V
V
F
T
A
P
F
V
A
Q
N
N
A
R
V
D
E
S
Q
R
I
S
F
P
L
V
A
D
R
W
L
A
A
N
V
E
L
L
G
N
L
V
F
A
A
A
T
C
A
V
L
S
1193
ABCC8 1190
L
D
T
T
L
L
L
H
F
E
T
V
E
G
T
T
I
R
A
F
E
A
R
F
Q
K
L
E
T
D
S
N
N
I
A
L
F
L
T
A
A
N
R
W
L
E
M
E
Y
G
C
V
V
I
A
V
T
S
I
S
N
1269
ABCC9 1162
E
L
D
D
S
T
Q
L
P
L
L
C
H
F
S
E
T
A
E
G
L
T
T
I
R
A
F
R
H
E
T
R
F
K
Q
L
E
L
T
D
T
N
N
I
A
Y
L
F
L
S
A
A
N
R
W
L
E
V
R
T
D
Y
L
G
A
C
I
V
L
T
A
S
I
A
S
I
S
G
1241
ABCC10 1094
R
L
G
S
L
T
L
S
P
L
Y
S
H
L
A
D
T
L
A
G
L
S
V
L
R
A
T
G
A
T
Y
R
F
E
E
E
N
L
R
L
L
E
L
N
Q
R
C
Q
F
A
T
S
A
T
M
Q
W
L
D
I
R
L
Q
L
M
G
A
A
V
V
S
A
I
A
G
I
A
L
V
Q
1173
ABCC11 989
R
L
E
Y
S
R
S
P
L
F
S
H
I
L
N
S
L
Q
G
L
S
S
I
H
V
Y
G
K
T
E
D
F
I
S
Q
F
K
R
L
T
D
A
Q
N
N
Y
L
L
L
F
L
S
S
T
R
W
M
A
L
R
L
E
I
M
T
N
L
V
T
L
A
V
A
L
F
V
A
F
G
1068
ABCC12 978
K
V
E
N
V
S
R
S
P
W
F
T
H
I
T
S
S
M
Q
G
L
G
I
I
H
A
Y
G
K
K
E
S
C
I
T
-
-
-
-
-
-
-
-
-
-
Y
H
L
L
Y
F
N
C
A
L
R
W
F
A
L
R
M
D
V
L
M
N
I
L
T
F
T
V
A
L
L
V
T
L
S
1047