ABCC11 p.Gly180Arg

Predicted by SNAP2: A: D (85%), C: D (95%), D: D (91%), E: D (95%), F: D (91%), H: D (91%), I: D (91%), K: D (91%), L: D (91%), M: D (91%), N: D (95%), P: D (95%), Q: D (85%), R: D (66%), S: D (75%), T: D (85%), V: D (91%), W: D (95%), Y: D (91%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Nakagawa H, Toyoda Y, Wakabayashi-Nakao K, Tamaki H, Osumi M, Ishikawa T
Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts.
J Pharm Sci. 2011 Sep;100(9):3602-19. doi: 10.1002/jps.22615. Epub 2011 May 12., [PMID:21567408]

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[hide] Keppler D
Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.
Handb Exp Pharmacol. 2011;(201):299-323., [PMID:21103974]

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[hide] Klaassen CD, Aleksunes LM
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
Pharmacol Rev. 2010 Mar;62(1):1-96. Epub 2010 Jan 26., [PMID:20103563]

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[hide] Ishikawa T
Recent advances in pharmacogenomics of ABC transporters involved in breast cancer therapy.
Pharmacogenomics. 2012 Apr;13(6):633-6., [PMID:22515603]

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[hide] Chen ZS, Tiwari AK
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
FEBS J. 2011 Sep;278(18):3226-45. doi: 10.1111/j.1742-4658.2011.08235.x. Epub 2011 Aug 1., [PMID:21740521]

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[hide] Lang T, Justenhoven C, Winter S, Baisch C, Hamann U, Harth V, Ko YD, Rabstein S, Spickenheuer A, Pesch B, Bruning T, Schwab M, Brauch H
The earwax-associated SNP c.538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans.
Breast Cancer Res Treat. 2011 Oct;129(3):993-9. Epub 2011 Jun 8., [PMID:21655989]

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[hide] Beesley J, Johnatty SE, Chen X, Spurdle AB, Peterlongo P, Barile M, Pensotti V, Manoukian S, Radice P, Chenevix-Trench G
No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women.
Breast Cancer Res Treat. 2011 Feb;126(1):235-9. Epub 2010 Dec 17., [PMID:21165769]

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[hide] Ohashi J, Naka I, Tsuchiya N
The impact of natural selection on an ABCC11 SNP determining earwax type.
Mol Biol Evol. 2011 Jan;28(1):849-57. Epub 2010 Oct 11., [PMID:20937735]

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[hide] Uemura T, Oguri T, Ozasa H, Takakuwa O, Miyazaki M, Maeno K, Sato S, Ueda R
ABCC11/MRP8 confers pemetrexed resistance in lung cancer.
Cancer Sci. 2010 Nov;101(11):2404-10. doi: 10.1111/j.1349-7006.2010.01690.x., [PMID:20718756]

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[hide] Inoue Y, Mori T, Toyoda Y, Sakurai A, Ishikawa T, Mitani Y, Hayashizaki Y, Yoshimura Y, Kurahashi H, Sakai Y
Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method.
J Plast Reconstr Aesthet Surg. 2010 Aug;63(8):1369-74. Epub 2009 Jul 21., [PMID:19625231]

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[hide] Martin A, Saathoff M, Kuhn F, Max H, Terstegen L, Natsch A
A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.
J Invest Dermatol. 2010 Feb;130(2):529-40. Epub 2009 Aug 27., [PMID:19710689]

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[hide] Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T
Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?
FASEB J. 2009 Jun;23(6):2001-13. Epub 2009 Apr 21., [PMID:19383836]

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[hide] Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo MT, Ishikawa T
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.
Xenobiotica. 2008 Jul;38(7-8):833-62., [PMID:18668432]

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[hide] Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko VA, Alipov GK, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano CK, Ghadami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray JC, Saito S, Nakamura Y, Niikawa N
A SNP in the ABCC11 gene is the determinant of human earwax type.
Nat Genet. 2006 Mar;38(3):324-30. Epub 2006 Jan 29., [PMID:16444273]

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[hide] Ota I, Sakurai A, Toyoda Y, Morita S, Sasaki T, Chishima T, Yamakado M, Kawai Y, Ishidao T, Lezhava A, Yoshiura K, Togo S, Hayashizaki Y, Ishikawa T, Ishikawa T, Endo I, Shimada H
Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.
Anticancer Res. 2010 Dec;30(12):5189-94., [PMID:21187511]

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[hide] Slot AJ, Molinski SV, Cole SP
Mammalian multidrug-resistance proteins (MRPs).
Essays Biochem. 2011 Sep 7;50(1):179-207. doi: 10.1042/bse0500179., [PMID:21967058]

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[hide] Ishikawa T, Toyoda Y, Yoshiura K, Niikawa N
Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion.
Front Genet. 2013 Jan 2;3:306. doi: 10.3389/fgene.2012.00306. eCollection 2012., [PMID:23316210]

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[hide] Rodriguez S, Steer CD, Farrow A, Golding J, Day IN
Dependence of deodorant usage on ABCC11 genotype: scope for personalized genetics in personal hygiene.
J Invest Dermatol. 2013 Jul;133(7):1760-7. doi: 10.1038/jid.2012.480. Epub 2013 Jan 17., [PMID:23325016]

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[hide] Honorat M, Terreux R, Falson P, Di Pietro A, Dumontet C, Payen L
Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models.
BMC Struct Biol. 2013 May 6;13:7. doi: 10.1186/1472-6807-13-7., [PMID:23641929]

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[hide] Harker M, Carvell AM, Marti VP, Riazanskaia S, Kelso H, Taylor D, Grimshaw S, Arnold DS, Zillmer R, Shaw J, Kirk JM, Alcasid ZM, Gonzales-Tanon S, Chan GP, Rosing EA, Smith AM
Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours.
J Dermatol Sci. 2014 Jan;73(1):23-30. doi: 10.1016/j.jdermsci.2013.08.016. Epub 2013 Sep 10., [PMID:24076068]

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[hide] Prokop-Prigge KA, Thaler E, Wysocki CJ, Preti G
Identification of volatile organic compounds in human cerumen.
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:48-52. doi: 10.1016/j.jchromb.2014.01.043. Epub 2014 Feb 5., [PMID:24572763]

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[hide] Stewart JC
Tomatoes cause under-arm odour.
Med Hypotheses. 2014 May;82(5):518-21. doi: 10.1016/j.mehy.2014.02.001. Epub 2014 Feb 13., [PMID:24576684]

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[hide] Matsumoto H, Tsuchiya T, Yoshiura K, Hayashi T, Hidaka S, Nanashima A, Nagayasu T
ABCC11/MRP8 Expression in the Gastrointestinal Tract and a Novel Role for Pepsinogen Secretion.
Acta Histochem Cytochem. 2014 Jun 28;47(3):85-94. doi: 10.1267/ahc.13040. Epub 2014 Jun 18., [PMID:25320405]

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[hide] Prokop-Prigge KA, Mansfield CJ, Parker MR, Thaler E, Grice EA, Wysocki CJ, Preti G
Ethnic/racial and genetic influences on cerumen odorant profiles.
J Chem Ecol. 2015 Jan;41(1):67-74. doi: 10.1007/s10886-014-0533-y. Epub 2014 Dec 13., [PMID:25501636]

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