ABCMdb

PMID: 18668432

Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo MT, Ishikawa T
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.
Xenobiotica. 2008 Jul;38(7-8):833-62., [PubMed]

Sentences

No. Mutations Sentence Comment

223 ABCC11 p.Gly180Arg By using a positional cloning and linkage disequilibrium analysis of genetics of earwax type, Yoshiura et al. (2006) revealed that the non-synonymous SNP (538G>A, Gly180Arg) in the MRP8 gene is the MRP class of human ABC transporters determinant of human earwax type. Login to comment 230 ABCC11 p.Gly180Arg Functional studies with MRP8-expressing LLC-PK1 cells demonstrated that cells expressing MRP8 with allele A (Gly180Arg) show a significantly lower level of cGMP transport, as compared with those expressing MRP8 wild-type with allele G (Yoshiura et al. 2006). Login to comment 233 ABCC11 p.Gly180Arg The non-synonymous SNP of 538 G > A (Gly180Arg) in the MRP8 gene exhibits wide ethnic differences in the allele frequency (Figure 5A). Login to comment