PMID: 21103974

Keppler D
Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.
Handb Exp Pharmacol. 2011;(201):299-323., [PubMed]
Sentences
No. Mutations Sentence Comment
265 ABCC11 p.Gly180Arg
X
ABCC11 p.Gly180Arg 21103974:265:83
status: NEW
view ABCC11 p.Gly180Arg details
 The single-nucleotide polymorphism 538G>A in the ABCC11 gene, corresponding to the Gly180Arg variant in human MRP8, determines the earwax type (Yoshiura et al. 2006; Toyoda et al. 2009) and prevents the secretion of amino acid conjugates determining human axillary odor (Martin et al. 2010). Login to comment 267 ABCC11 p.Gly180Arg
X
ABCC11 p.Gly180Arg 21103974:267:4
status: NEW
view ABCC11 p.Gly180Arg details
 The Gly180Arg variant lacks N-linked glycosylation and is recognized as a misfolded protein undergoing proteasomal degradation (Toyoda et al. 2009). Login to comment