PMID: 21740521

Chen ZS, Tiwari AK
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
FEBS J. 2011 Sep;278(18):3226-45. doi: 10.1111/j.1742-4658.2011.08235.x. Epub 2011 Aug 1., [PubMed]
Sentences
No. Mutations Sentence Comment
242 ABCC11 p.Gly180Arg
X
ABCC11 p.Gly180Arg 21740521:242:223
status: NEW
view ABCC11 p.Gly180Arg details
 MRP8 / ABCC11 and dry /wet ear wax Insight into a physiological role for MRP8 in cerumen (ear wax) secretion by the ceruminous apocrine glands was revealed by the identification of a single nucleotide polymorphism, 538G>A (Gly180Arg) in the MRP8 gene, which was associated with the production of wet rather than dry ear wax [184]. Login to comment 248 ABCC11 p.Gly180Arg
X
ABCC11 p.Gly180Arg 21740521:248:34
status: NEW
view ABCC11 p.Gly180Arg details
 In membrane vesicles studies, the G180R mutant of MRP8 was unable to transport cAMP, again supporting the notion that a deficiency of MRP8 transport activity is responsible for the dry ear wax type. Login to comment